Androxy

Pronunciation: floo-ox-i-MES-te-rone
Generic Name: Fluoxymesterone
Brand Name: Androxy

Androxy is used for:

Treating a deficiency of the male hormone testosterone when the body does not make enough. It is also used to stimulate puberty in males with delayed puberty.Treating advanced breast cancer in women who are 1 to 5 years past menopause.

Androxy is an androgen.It works by stimulating normal growth and development of the male sex organs and maintaining normal secondary sex characteristics.It is unknown exactly how Androxy works to treat breast cancer.

Do NOT use Androxy if:

• you are allergic to any ingredient in Androxy


• you are pregnant or planning to become pregnant


• you have breast cancer or prostate cancer

Contact your doctor or health care provider right away if any of these apply to you.

Before using Androxy:

Some medical conditions may interact with Androxy. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have prostate problems, high blood calcium levels, or heart, liver, or kidney disease

Some MEDICINES MAY INTERACT with Androxy. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), carbamazepine, corticosteroids (eg, prednisone), macrolide immunosuppressants (eg, tacrolimus), or oxyphenbutazone because the actions and side effects of these medicines may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Androxy may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Androxy:

Use Androxy as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Androxy may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• If you miss a dose of Androxy, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Androxy.

Important safety information:

• Androxy may contain tartrazine dye (FD&C Yellow No. 5), which can cause allergic reactions in certain patients. If you have previously had an allergic reaction to tartrazine, contact your pharmacist to determine if the medicine you are taking contains tartrazine.


• Diabetes patients - Androxy may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.


• LAB TESTS, including liver function and blood cholesterol, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.


• Young males who are taking Androxy for delayed puberty should be checked for bone development every 6 months.


• Use Androxy with caution in the ELDERLY because they may be more sensitive to its effects, especially prostate problems.


• Androxy is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Do not use Androxy if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. It is unknown if Androxy is excreted in breast milk. Do not breast-feed while taking Androxy.

Possible side effects of Androxy:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in sexual desire; absence of menstrual flow; acne; breast swelling or tenderness; deepening of voice; growth of facial hair; headache; irregular menstrual flow; mood changes; painful, prolonged erection; swelling of the clitoris.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); ankle swelling; change in skin color; nausea; vomiting; weight gain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Androxy side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Androxy:

Store Androxy at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Androxy out of the reach of children and away from pets.

General information:

• If you have any questions about Androxy, please talk with your doctor, pharmacist, or other health care provider.


• Androxy is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Androxy. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Androxy resources

• Androxy Side Effects (in more detail)
• Androxy Use in Pregnancy & Breastfeeding
• Androxy Drug Interactions
• Androxy Support Group
• 0 Reviews for Androxy - Add your own review/rating

• Androxy Concise Consumer Information (Cerner Multum)


• Androxy Prescribing Information (FDA)


• Fluoxymesterone Professional Patient Advice (Wolters Kluwer)


• Fluoxymesterone Monograph (AHFS DI)


• Halotestin Prescribing Information (FDA)

Compare Androxy with other medications

• Breast Cancer
• Breast Cancer, Palliative
• Delayed Puberty, Male
• Hypogonadism, Male
• Postmenopausal Symptoms

spironolactone

spir-on-oh-LAK-tone

Oral route(Tablet)

Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats. Spironolactone should be used only in those conditions specified as indications for use. Unnecessary use of this drug should be avoided .

Commonly used brand name(s)

In the U.S.

• Aldactone

Available Dosage Forms:

• Tablet

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Aldosterone Receptor Antagonist

Uses For spironolactone

Spironolactone is used in combination with other medicines to treat high blood pressure (hypertension) and heart failure. It may also be used to treat water retention (edema) in patients with congestive heart failure, liver cirrhosis, or a kidney disorder called nephrotic syndrome.

Spironolactone is also used to diagnose and treat hyperaldosteronism, a condition in which the adrenal gland produces too much hormone called aldosterone.

Spironolactone is a type of a diuretic medicine (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. It can be used to prevent or treat hypokalemia (low potassium levels in the blood).

spironolactone is available only with your doctor’s prescription.

Before Using spironolactone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For spironolactone, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to spironolactone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of spironolactone in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of spironolactone in geriatric patients.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking spironolactone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using spironolactone with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Eplerenone


• Triamterene

Using spironolactone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alacepril


• Arginine


• Arsenic Trioxide


• Benazepril


• Captopril


• Cilazapril


• Delapril


• Digoxin


• Droperidol


• Enalaprilat


• Enalapril Maleate


• Fosinopril


• Imidapril


• Levomethadyl


• Lisinopril


• Lithium


• Moexipril


• Pentopril


• Perindopril


• Potassium


• Quinapril


• Ramipril


• Sotalol


• Spirapril


• Tacrolimus


• Temocapril


• Trandolapril


• Zofenopril

Using spironolactone with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aceclofenac


• Acemetacin


• Alclofenac


• Apazone


• Benoxaprofen


• Bromfenac


• Bufexamac


• Carprofen


• Clometacin


• Clonixin


• Dexketoprofen


• Diclofenac


• Diflunisal


• Digitoxin


• Dipyrone


• Droxicam


• Etodolac


• Etofenamate


• Felbinac


• Fenbufen


• Fenoprofen


• Fentiazac


• Floctafenine


• Flufenamic Acid


• Flurbiprofen


• Gossypol


• Ibuprofen


• Indomethacin


• Indoprofen


• Isoxicam


• Ketoprofen


• Ketorolac


• Licorice


• Lornoxicam


• Meclofenamate


• Mefenamic Acid


• Meloxicam


• Nabumetone


• Naproxen


• Niflumic Acid


• Nimesulide


• Oxaprozin


• Oxyphenbutazone


• Phenylbutazone


• Pirazolac


• Piroxicam


• Pirprofen


• Propyphenazone


• Proquazone


• Sulindac


• Suprofen


• Tenidap


• Tenoxicam


• Tiaprofenic Acid


• Tolmetin


• Zomepirac

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of spironolactone. Make sure you tell your doctor if you have any other medical problems, especially:

• Anuria (not able to pass urine) or


• Hyperkalemia (high potassium in the blood) or


• Kidney disease, severe—Should not be used in patients with these conditions.

• Electrolyte imbalance (e.g., low chloride, magnesium, potassium, or sodium in the body) or


• Fluid imbalances (caused by dehydration, vomiting, or diarrhea) or


• Liver disease, severe (e.g., cirrhosis)—Use with caution. May make these conditions worse.

Proper Use of spironolactone

In addition to the use of spironolactone, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt) and potassium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that spironolactone will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Dosing

The dose of spironolactone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of spironolactone. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For edema:
    
    • Adults—At first, 100 milligrams (mg) per day, given in either single or divided doses. Your doctor may adjust your dose if needed.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For heart failure:
    
    • Adults—At first, 25 milligrams (mg) per day. Your doctor may adjust your dose if needed and tolerated.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For high blood pressure:
    
    • Adults—At first, 50 to 100 milligrams (mg) per day, given in either single or divided doses. Your doctor may adjust your dose if needed.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For low potassium in the blood:
    
    • Adults—25 to 100 milligrams (mg) per day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For too much aldosterone in the body:
    
    • Adults—400 milligrams (mg) for 4 days, or 400 mg per day for 3 to 4 weeks to diagnose the condition. Then, 100 to 400 mg per day after the diagnosis is confirmed.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of spironolactone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using spironolactone

It is very important that your doctor check your progress at regular visits to make sure spironolactone is working properly and to decide if you should continue to take it. Blood tests may be needed to check for unwanted effects.

Do not take other medicines unless they have been discussed with your doctor. This especially includes potassium supplements or salt substitutes containing potassium; or certain diuretics such as amiloride (Midamor®, Moduretic®), triamterene (Dyazide®, Dyrenium®, Maxzide®), or other products containing spironolactone (Aldactazide®).

spironolactone may increase the amount of potassium in your blood (hyperkalemia). Stop using spironolactone and check with your doctor right away if you are having abdominal or stomach pain; confusion; difficulty with breathing; irregular heartbeat; nausea or vomiting; nervousness; numbness or tingling in the hands, feet, or lips; shortness of breath; or weakness or heaviness of the legs.

Check with your doctor right away if you become sick while taking spironolactone, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water or salt.

Check with your doctor right away if you experience dizziness, fainting, confusion, muscle pain, weakness, and/or a fast heartbeat. Use extra care if you exercise or if the weather is hot. Heavy sweating can cause dehydration (loss of too much water) or electrolyte imbalances (loss of sodium, potassium, or magnesium in the body).

spironolactone may cause swelling of the breasts (gynecomastia) and breast pain in some patients. If you have questions about this, talk to your doctor.

Make sure any doctor or dentist who treats you knows that you are using spironolactone. You may need to stop using spironolactone several days before having medical tests. The results of some tests may be affected by spironolactone.

spironolactone may cause the formation of certain tumors in your body. Check with your doctor right away if you notice an unusual lump anywhere in your body or if you have any unusual signs or symptoms while you are using spironolactone.

spironolactone Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

• Abdominal or stomach cramping, burning, or tenderness


• bloody or black, tarry stools


• bloody urine


• chills


• clay-colored stools


• clear or bloody discharge from the nipple


• cloudy urine


• constipation


• cough or hoarseness


• dark urine


• decrease in urine output or decrease in urine-concentrating ability


• decreased appetite


• diarrhea


• difficulty with swallowing


• dimpling of the breast skin


• dizziness


• fast heartbeat


• fever with or without chills


• general feeling of tiredness or weakness


• headache


• heartburn


• hives


• increased blood pressure


• increased thirst


• indigestion


• inverted nipple


• itching


• loss of appetite


• lower back or side pain


• lump in the breast or under the arm


• nausea and vomiting


• painful or difficult urination


• persistent crusting or scaling of the nipple


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• redness or swelling of the breast


• severe stomach pain


• shakiness and unsteady walk


• shortness of breath


• skin rash


• sore on the skin of the breast that does not heal


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• swelling of the face, fingers, feet, or lower legs


• swollen, painful, or tender lymph glands in the neck, armpit, or groin


• tightness in the chest


• troubled breathing


• unpleasant breath odor


• unsteadiness, trembling, or other problems with muscle control or coordination


• unusual bleeding or bruising


• unusual tiredness or weakness


• vomiting of blood or material that looks like coffee grounds


• weight gain


• wheezing


• yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Coma


• confusion


• convulsions


• difficulty with breathing


• drowsiness


• irregular heartbeat


• muscle pain or cramps


• nervousness


• numbness or tingling in the hands, feet, or lips


• rash with flat lesions or small raised lesions on the skin


• reddened skin


• swelling of the ankles or hands


• weakness or heaviness of the legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Burning feeling in the chest or stomach


• sores, welting, or blisters


• stomach upset


• swelling of the breasts or breast soreness in both females and males


• unusual dullness or feeling of sluggishness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: spironolactone side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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More spironolactone resources

• Spironolactone Side Effects (in more detail)
• Spironolactone Dosage
• Spironolactone Use in Pregnancy & Breastfeeding
• Drug Images
• Spironolactone Drug Interactions
• Spironolactone Support Group
• 46 Reviews for Spironolactone - Add your own review/rating

• Spironolactone Prescribing Information (FDA)


• Spironolactone Professional Patient Advice (Wolters Kluwer)


• Spironolactone Monograph (AHFS DI)


• Spironolactone MedFacts Consumer Leaflet (Wolters Kluwer)


• Aldactone Prescribing Information (FDA)


• Aldactone Consumer Overview

Compare spironolactone with other medications

• Acne
• Alopecia
• Edema
• Heart Failure
• High Blood Pressure
• Hirsutism
• Hypokalemia
• Primary Hyperaldosteronism
• Primary Hyperaldosteronism Diagnosis

Influbene C

Influbene C may be available in the countries listed below.

Ingredient matches for Influbene C

Ascorbic Acid

Ascorbic Acid is reported as an ingredient of Influbene C in the following countries:

• Switzerland

Paracetamol

Paracetamol is reported as an ingredient of Influbene C in the following countries:

• Switzerland

International Drug Name Search

Solifenacin Succinate

Class: Genitourinary Smooth Muscle Relaxants
Chemical Name: (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate cmpd. with butanedioic acid (1:1)
Molecular Formula: C₂₃H₂₆N₂O₂•C₄H₆O₄
CAS Number: 242478-38-2
Brands: Vesicare

Introduction

Genitourinary antispasmodic agent; an antimuscarinic agent.¹

Uses for Solifenacin Succinate

Overactive Bladder

Relief of symptoms associated with voiding (e.g., urge urinary incontinence, urgency, frequency).¹

Solifenacin Succinate Dosage and Administration

Administration

Oral Administration

Administer orally once daily with liquids without regard to meals.^{1 8}

Swallow tablets whole.^{1 8}

Dosage

Available as solifenacin succinate; dosage expressed in terms of the salt.¹

Adults

Overactive Bladder

Oral

Initially, 5 mg once daily.¹ If well tolerated, may increase to 10 mg once daily.¹

Prescribing Limits

Adults

Overactive Bladder

Oral

Maximum 10 mg daily.¹

Special Populations

Hepatic Impairment

Maximum 5 mg daily in patients with moderate hepatic impairment (Child-Pugh class B).¹ (See Elimination: Special Populations, under Pharmacokinetics.)

Use not recommended in patients with severe hepatic impairment (Child-Pugh class C).¹

Renal Impairment

Maximum 5 mg daily in patients with severe renal impairment (Cl_cr <30 mL/minute).¹ (See Elimination: Special Populations, under Pharmacokinetics.)

Cautions for Solifenacin Succinate

Contraindications

• 
  

  Urinary retention, gastric retention, or uncontrolled angle-closure glaucoma.¹

  
  


• 
  

  Known hypersensitivity to solifenacin succinate or any ingredient in the formulation.¹

  
  

Warnings/Precautions

Sensitivity Reactions

Angioedema

Angioedema reported in at least 1 patient.^{1 9}

General Precautions

Urinary Retention

Risk of urinary retention; use with caution in patients with clinically important bladder outflow obstruction.¹

Decreased GI Motility

Use with caution in patients with decreased GI motility¹ (e.g., patients with severe constipation, ulcerative colitis, or myasthenia gravis) or obstructive GI disorders.⁹

Fecal impaction, colonic obstruction, and intestinal obstruction reported rarely with 10-mg daily dosage.¹

Prolongation of QT Interval

30-mg daily dosage associated with more pronounced prolongation of QT interval than 10-mg daily dosage.¹ (See Prescribing Limits under Dosage and Administration.) Consider this observation when deciding to use solifenacin in patients with history of QT interval prolongation or receiving drugs that prolong QT interval.¹

Controlled Angle-closure Glaucoma

Use with caution in patients being treated for angle-closure glaucoma.¹ (See Contraindications under Cautions.)

Specific Populations

Pregnancy

Category C.¹

Lactation

Distributed into milk in mice; not known whether distributed into human milk.¹ Discontinue nursing or the drug.¹

Pediatric Use

Safety and efficacy not established in children <18 years of age.⁹

Geriatric Use

No substantial differences in safety and efficacy relative to younger adults.¹ (See Elimination: Special Populations, under Pharmacokinetics.)

Hepatic Impairment

Use with caution.¹ (See Hepatic Impairment under Dosage and Administration and see Elimination: Special Populations, under Pharmacokinetics.)

Use not recommended in patients with severe hepatic impairment (Child-Pugh class C).¹

Renal Impairment

Use with caution.¹ (See Renal Impairment under Dosage and Administration and see Elimination: Special Populations, under Pharmacokinetics.)

Common Adverse Effects

Dry mouth, constipation.¹

Interactions for Solifenacin Succinate

Metabolized principally by CYP3A4.¹ Does not inhibit CYP1A1/2, 2C9, 2C19, 2D6, or 3A4.¹

Drugs Affecting Hepatic Microsomal Enzymes

Inhibitors of CYP3A4: Potential pharmacokinetic interaction (increased plasma solifenacin concentrations).¹ Do not exceed 5 mg daily when used concomitantly with potent inhibitors of CYP3A4.¹ (See Specific Drugs under Interactions.)

Inducers of CYP3A4: Potential pharmacokinetic interaction (altered solifenacin pharmacokinetics).¹

Drugs Metabolized by Hepatic Microsomal Enzymes

Substrates of CYP1A1/2, CYP2C9, CYP2C19, CYP2D6, or CYP3A4: Pharmacokinetic interaction unlikely

Drugs Affected by GI Motility

Potential pharmacokinetic interaction (altered absorption because of decreased GI motility).¹⁰ (See Decreased GI Motility under Cautions.)

Specific Drugs

Drug	Interaction	Comments
Anticholinergic agents	Possible additive anticholinergic effects9
Digoxin	No substantial effect on digoxin pharmacokinetics1
Hormonal contraceptives	No substantial changes in plasma concentrations of ethinyl estradiol or levonorgestrel1
Ketoconazole	Increased plasma solifenacin concentrations1	Do not exceed a solifenacin succinate dosage of 5 mg daily1
Warfarin	No substantial effect on warfarin pharmacokinetics1

Solifenacin Succinate Pharmacokinetics

Absorption

Bioavailability

Absolute bioavailability is approximately 90%.^{1 6}

Peak plasma concentrations achieved within 3–8 hours after administration.¹

Food

Food does not affect pharmacokinetics of solifenacin.^{1 7}

Special Populations

Increased plasma concentrations reported in geriatric patients, patients with moderate hepatic impairment (Child-Pugh class B), and patients with severe renal impairment (Cl_cr <30 mL/minute).¹ (See Special Populations under Dosage and Administration and see Elimination: Special Populations, under Pharmacokinetics.)

Distribution

Extent

Highly distributed to tissues outside the CNS.¹

Distributed into milk in mice; not known whether distributed into human milk.¹

Plasma Protein Binding

Approximately 98% (mainly to α₁-acid glycoprotein).¹

Elimination

Metabolism

Extensively metabolized in the liver, mainly via CYP3A4.¹

Elimination Route

Excreted in urine (approximately 69%) and in feces (approximately 23%); unchanged drug accounts for <15% of recovered radioactivity.¹

Half-life

45–68 hours following long-term administration.¹

Special Populations

Prolonged half-life in geriatric patients, patients with moderate hepatic impairment (Child-Pugh class B), and patients with severe renal impairment (Cl_cr <30 mL/minute).¹ (See Special Populations under Dosage and Administration.)

Stability

Storage

Oral

Tablets

25°C (may be exposed to 15–30°C).¹

ActionsActions

• 
  

  Potent and selective antimuscarinic agent.^{1 2}

  
  


• 
  

  Inhibits contraction of the detrusor muscle of the bladder, resulting in decreased bladder activity.²

  
  


• 
  

  Demonstrates binding specificity for muscarinic M₃ receptors in vitro and functional selectivity for urinary bladder over secretory (e.g., salivary) glands.²

  
  

Advice to Patients

• 
  

  Risk of blurred vision, constipation, dry mouth, and heat prostration (when used in a hot environment).¹ Use caution when driving or performing dangerous activities until effects on vision are known.⁸ Consult a clinician if severe abdominal pain occurs or if constipation persists for ≥3 days.¹

  
  


• 
  

  Importance of taking solifenacin succinate with liquids and swallowing the tablet whole.^{1 8} If a dose is skipped, resume therapy the next day; do not take 2 doses in the same day.⁸

  
  


• 
  

  Importance of reading manufacturer’s patient information leaflet before initiating therapy.¹

  
  


• 
  

  Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs and dietary or herbal supplements, as well as any concomitant illnesses.¹

  
  


• 
  

  Importance of women informing their clinician if they are or plan to become pregnant or plan to breast-feed.¹

  
  


• 
  

  Importance of informing patients of other important precautionary information. (See Cautions.)

  
  

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Solifenacin Succinate

Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Oral	Tablets, film-coated	5 mg	Vesicare	Yamanouchi (also promoted by GlaxoSmithKline)
		10 mg	Vesicare	Yamanouchi (also promoted by GlaxoSmithKline)

Comparative Pricing

This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.

VESIcare 10MG Tablets (ASTELLAS): 30/$161.99 or 90/$458.96

VESIcare 5MG Tablets (ASTELLAS): 30/$165.98 or 90/$475.95

Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions July 2005. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

References

1. Yamanouchi. VESIcare (solifenacin succinate) tablets prescribing information. Paramus, NJ; 2004 Nov.

2. Chilman-Blair K. Solifenacin: Treatment of overactive bladder. Drugs Today. 2004; 40:343-53. [PubMed 15190387]

3. Chapple CR, Rechberger T, Al-Shukri S et al. Randomized, double-blind placebo- and tolterodine-controlled trial of the once-daily antimuscarinic agent solifenacin in patients with symptomatic overactive bladder. BJU Int. 2004; 93:303-10. [IDIS 532014] [PubMed 14764127]

4. Cardozo L, Lisec M, Millard R et al. Randomized, double-blind placebo controlled trial of the once daily antimuscarinic agent solifenacin succinate in patients with overactive bladder. J Urol. 2004; 172:1919-24. [IDIS 522716] [PubMed 15540755]

5. Kelleher CJ, Cardozo L, Chapple CR et al. Improved quality of life in patients with overactive bladder symptoms treated with solifenacin. BJU Int. 2005; 95:81-5. [IDIS 532015] [PubMed 15638900]

6. Kuipers ME, Krauwinkel WJJ, Mulder H et al. Solifenacin demonstrates high absolute bioavailability in healthy men. Drugs R D. 2004; 5:73-81. [PubMed 15293866]

7. Uchida T, Krauwinkel WJ, Mulder H et al. Food does not affect the pharmacokinetics of solifenacin, a new muscarinic receptor antagonist: results of a randomized crossover trial. Br J Clin Pharmacol. 2004; 58:4-7. [IDIS 519282] [PubMed 15206986]

8. Yamanouchi. VESIcare (solifenacin succinate) patient information. Paramus, NJ; 2004 Nov.

9. Astellas Pharma, Durham, NC: Personal communication.

10. Novartis. Enablex (darifenacin hydrobromide) extended-release tablets prescribing information. East Hanover, NJ; 2004 Dec.

More Solifenacin Succinate resources

• Solifenacin Succinate Side Effects (in more detail)
• Solifenacin Succinate Dosage
• Solifenacin Succinate Use in Pregnancy & Breastfeeding
• Solifenacin Succinate Drug Interactions
• Solifenacin Succinate Support Group
• 32 Reviews for Solifenacin Succinate - Add your own review/rating

Compare Solifenacin Succinate with other medications

• Overactive Bladder
• Urinary Incontinence

Librium

Generic Name: chlordiazepoxide hydrochloride (Oral route)

klor-dye-az-e-POX-ide hye-droe-KLOR-ide

Commonly used brand name(s)

In the U.S.

• Librium

Available Dosage Forms:

• Capsule


• Tablet

Therapeutic Class: Antianxiety

Pharmacologic Class: Chlordiazepoxide

Uses For Librium

Chlordiazepoxide is used to relieve symptoms of anxiety, including nervousness or anxiety that happens before a surgery. It may also be used to treat symptoms of alcohol withdrawal.

Chlordiazepoxide is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.

Before Using Librium

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of chlordiazepoxide in children below 6 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of chlordiazepoxide in the elderly. However, severe drowsiness, dizziness, confusion, clumsiness, or unsteadiness are more likely to occur in the elderly, who are usually more sensitive than younger adults to the effects of chlordiazepoxide. Elderly patients may require a lower dose to help reduce unwanted effects.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alfentanil


• Amobarbital


• Anileridine


• Aprobarbital


• Butabarbital


• Butalbital


• Carisoprodol


• Chloral Hydrate


• Chlorzoxazone


• Codeine


• Dantrolene


• Ethchlorvynol


• Fentanyl


• Fospropofol


• Hydrocodone


• Hydromorphone


• Levorphanol


• Meperidine


• Mephenesin


• Mephobarbital


• Meprobamate


• Metaxalone


• Methocarbamol


• Methohexital


• Morphine


• Morphine Sulfate Liposome


• Oxycodone


• Oxymorphone


• Pentobarbital


• Phenobarbital


• Primidone


• Propoxyphene


• Remifentanil


• Secobarbital


• Sodium Oxybate


• Sufentanil


• Tapentadol


• Thiopental


• Zolpidem

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Ketoconazole


• St John's Wort


• Theophylline

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Kidney disease or


• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

• Porphyria (genetic disorder)—Use with caution. May make this condition worse.

Proper Use of chlordiazepoxide hydrochloride

This section provides information on the proper use of a number of products that contain chlordiazepoxide hydrochloride. It may not be specific to Librium. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (capsules):
  
  • For anxiety:
    
    • Adults—5 to 25 milligrams (mg) three or four times a day.
    
    
    • Older adults—5 milligrams (mg) two to four times a day.
    
    
    • Children 6 years of age and older—At first, 5 milligrams (mg) two to four times a day. Your doctor may increase your dose if needed.
    
    
    • Children younger than 6 years of age—Use and dose must be determined by your doctor.
    
    
  
  
  • For apprehension and anxiety before a surgery:
    
    • Adults—5 to 10 milligrams (mg) three or four times a day, taken several days before the surgery.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For symptoms of alcohol withdrawal:
    
    • Adults—At first, 50 to 100 milligrams (mg). The dose may be repeated until agitation is controlled. However, the dose is usually not more than 300 mg per day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Librium

It is very important that your doctor check the progress of you or your child at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine may cause some people, especially older persons, to become drowsy, dizzy, lightheaded, clumsy or unsteady, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert or able to think or see well.

This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system, which may cause drowsiness or make you less alert. Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates (used for seizures); muscle relaxants; or anesthetics (numbing medicines), including some dental anesthetics. This effect may last for a few days after you stop taking this medicine. Check with your doctor before taking any of the above while you are using this medicine.

If you develop any unusual and strange thoughts or behavior while you are taking chlordiazepoxide, be sure to discuss it with your doctor. Some changes that have occurred in people taking this medicine are like those seen in people who drink alcohol and then act in a manner that is not normal. Other changes may be more unusual and extreme, such as confusion, worsening of depression, hallucinations (seeing, hearing, or feeling things that are not there), suicidal thoughts, and unusual excitement, nervousness, or irritability.

Do not stop taking it without checking with your doctor first.. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent a worsening of your condition and reduce the possibility of withdrawal symptoms, such as convulsions (seizures), stomach or muscle cramps, tremors, or unusual behavior.

This medicine is for short-term use only (usually 7 to 10 days). If your condition does not improve or if it becomes worse, check with your doctor.

Librium Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

• Fainting


• mood or mental changes


• shakiness and unsteady walk


• unsteadiness, trembling, or other problems with muscle control or coordination

Incidence not known

• Abdominal and muscle cramps


• chills


• clay-colored stools


• convulsions


• cough or hoarseness


• dark urine


• difficulty in speaking


• dizziness


• drooling


• fever with or without chills


• general feeling of tiredness or weakness


• headache


• itching


• light-colored stools


• loss of appetite


• loss of balance control


• lower back or side pain


• muscle trembling, jerking, or stiffness


• nausea and vomiting


• painful or difficult urination


• pale skin


• rash


• restlessness


• shakiness in the legs, arms, hands, or feet


• shuffling walk


• sleeplessness


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• stiffness of the limbs


• stomach pain


• sweating


• swelling


• trouble sleeping


• twisting movements of the body


• unable to sleep


• uncontrolled movements, especially of the face, neck, and back


• unpleasant breath odor


• unusual bruising or bleeding


• unusual tiredness or weakness


• vomiting of blood


• yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Change in consciousness


• lack of coordination


• loss of consciousness


• sleepiness or unusual drowsiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Decreased interest in sexual intercourse


• difficulty having a bowel movement (stool)


• inability to have or keep an erection


• increased in sexual ability, desire, drive, or performance


• increased interest in sexual intercourse


• loss in sexual ability, desire, drive, or performance


• menstrual changes


• skin blisters

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Librium side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Librium resources

• Librium Side Effects (in more detail)
• Librium Use in Pregnancy & Breastfeeding
• Drug Images
• Librium Drug Interactions
• Librium Support Group
• 32 Reviews for Librium - Add your own review/rating

• Librium Prescribing Information (FDA)


• Librium MedFacts Consumer Leaflet (Wolters Kluwer)


• Librium Concise Consumer Information (Cerner Multum)


• Librium Monograph (AHFS DI)


• Chlordiazepoxide Prescribing Information (FDA)


• Chlordiazepoxide Professional Patient Advice (Wolters Kluwer)

Compare Librium with other medications

• Alcohol Withdrawal
• Anxiety
• Light Sedation

Mefoxin

Generic Name: cefoxitin (sef OX i tin)

Brand Names: Mefoxin

What is cefoxitin injection?

Cefoxitin is in a group of drugs called cephalosporin (SEF a low spor in) antibiotics. It works by fighting bacteria in your body.

Cefoxitin is used to treat many kinds of bacterial infections, including severe or life-threatening forms.

Cefoxitin may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Mefoxin (cefoxitin)?

Do not use this medication if you are allergic to cefoxitin, or to similar antibiotics, such as Ceftin, Cefzil, Keflex, Omnicef, and others.

Before using this medication, tell your doctor if you are allergic to any drugs (especially penicillin). Also tell your doctor if you have liver or kidney disease, diabetes, heart failure, cancer, a stomach or intestinal disorder, or if you are malnourished.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Cefoxitin will not treat a viral infection such as the common cold or flu.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

This medication can cause you to have unusual results with certain lab tests, including tests to check for glucose (sugar) in the urine. Tell any doctor who treats you that you are using cefoxitin.

What should I discuss with my health care provider before using cefoxitin injection?

Do not use this medication if you are allergic to cefoxitin, or to other cephalosporin antibiotics, such as:

• 
  

  cefaclor (Raniclor);

  
  


• 
  

  cefadroxil (Duricef);

  
  


• 
  

  cefazolin (Ancef);

  
  


• 
  

  cefdinir (Omnicef);

  
  


• 
  

  cefditoren (Spectracef);

  
  


• 
  

  cefpodoxime (Vantin);

  
  


• 
  

  cefprozil (Cefzil);

  
  


• 
  

  ceftibuten (Cedax);

  
  


• 
  

  cefuroxime (Ceftin);

  
  


• 
  

  cephalexin (Keflex);

  
  


• 
  

  cephradine (Velosef); and others.

  
  

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take cefoxitin:

• 
  

  kidney disease;

  
  


• 
  

  liver disease;

  
  


• 
  

  a stomach or intestinal disorder such as colitis;

  
  


• 
  

  diabetes;

  
  


• 
  

  congestive heart failure;

  
  


• 
  

  cancer;

  
  


• 
  

  if you are malnourished; or

  
  


• 
  

  if you have had a very recent surgery or medical emergency.

  
  

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Cefoxitin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How is cefoxitin given?

Cefoxitin is given as an injection through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection. You may be given instructions on how to inject your medicine at home. Do not use this medicine at home if you do not fully understand how to give the injection and properly dispose of needles and other items used in giving the medicine.

Use the medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Cefoxitin will not treat a viral infection such as the common cold or flu.

This medication can cause you to have unusual results with certain lab tests, including tests to check for glucose (sugar) in the urine. Tell any doctor who treats you that you are using cefoxitin.

To be sure this medication is helping your condition, your blood may need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

If you keep this medicine at home, store it in a deep freezer at a temperature of 4 degrees below 0.

To use the medicine, thaw it in a refrigerator or at room temperature. Do not warm in a microwave or boiling water. Keep thawed medicine in the refrigerator and use it within 28 days after thawing it. Do not refreeze.

Do not use the medication if it looks cloudy or has any particles in it. Call your doctor for a new prescription.

What happens if I miss a dose?

Use the medication as soon as you remember the missed dose. If it is almost time for your next dose, skip the missed dose and use the medicine at your next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a cefoxitin overdose may include seizure (convulsions).

What should I avoid while using Mefoxin (cefoxitin)?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Mefoxin (cefoxitin) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  diarrhea that is watery or bloody;

  
  


• 
  

  fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

  
  


• 
  

  swelling, pain, or irritation where the injection was given;

  
  


• 
  

  skin rash, bruising, severe tingling, numbness, pain, muscle weakness;

  
  


• 
  

  feeling light-headed, fainting;

  
  


• 
  

  easy bruising or bleeding, unusual weakness;

  
  


• 
  

  fever, chills, body aches, flu symptoms;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  seizure (black-out or convulsions); or

  
  


• 
  

  jaundice (yellowing of the eyes or skin).

  
  

Less serious side effects are more likely to occur, such as:

• 
  

  nausea, vomiting, stomach pain;

  
  


• 
  

  mild skin rash; or

  
  


• 
  

  vaginal itching or discharge.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Mefoxin (cefoxitin)?

Before using cefoxitin, tell your doctor if you are using any of the following drugs:

• 
  

  an antibiotic such as amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), neomycin (Mycifradin, Neo-Fradin, Neo-Tab), netilmicin (Netromycin), streptomycin, or tobramycin (Nebcin, Tobi).

  
  

This list is not complete and there may be other drugs that can interact with cefoxitin. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More Mefoxin resources

• Mefoxin Side Effects (in more detail)
• Mefoxin Use in Pregnancy & Breastfeeding
• Mefoxin Drug Interactions
• Mefoxin Support Group
• 0 Reviews for Mefoxin - Add your own review/rating

• Mefoxin Prescribing Information (FDA)


• Mefoxin MedFacts Consumer Leaflet (Wolters Kluwer)


• Mefoxin Monograph (AHFS DI)


• Mefoxin Advanced Consumer (Micromedex) - Includes Dosage Information


• Cefoxitin Prescribing Information (FDA)

Compare Mefoxin with other medications

• Aspiration Pneumonia
• Bone infection
• Cesarean Section
• Cholecystitis
• Deep Neck Infection
• Endometritis
• Gonococcal Infection, Uncomplicated
• Intraabdominal Infection
• Joint Infection
• Kidney Infections
• Pelvic Inflammatory Disease
• Peritonitis
• Pneumonia
• Septicemia
• Skin and Structure Infection
• Skin Infection
• Surgical Prophylaxis
• Urinary Tract Infection

Where can I get more information?

• Your doctor or pharmacist has information about cefoxitin written for health professionals that you may read.

See also: Mefoxin side effects (in more detail)

Mollifene otic

Generic Name: carbamide peroxide (otic) (KAR ba mide per OX ide OH tik)

Brand Names: Auraphene-B, Auro Ear Drops, Debrox, Ear Wax, Ear Wax Removal, Mollifene, Murine Ear Drops

What is carbamide peroxide?

Carbamide peroxide otic (for the ears) is used to soften and loosen ear wax, making it easier to remove.

Carbamide peroxide may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about carbamide peroxide?

You should not use this medication if you are allergic to carbamide peroxide, or if you have a ruptured ear drum. Do not use carbamide peroxide if you have any signs of ear infection or injury, such as pain or other irritation, or drainage, discharge, or bleeding from the ear. Do not use this medication in a child younger than 12 years old without the advice of a doctor.

You may hear a bubbling sound inside your ear after using carbamide peroxide ear drops. This is caused by the foaming action of carbamide peroxide, which helps break up the wax inside your ear.

Do not use carbamide peroxide for longer than 4 days in a row. Call your doctor if your ear symptoms do not improve after treatment, or if they get worse. Stop using carbamide peroxide and call your doctor at once if you have a serious side effect such as dizziness, ear pain or other irritation, decreased hearing for a prolonged period of time, or discharge or bleeding from the ear.

What should I discuss with my health care provider before using carbamide peroxide?

You should not use this medication if you are allergic to carbamide peroxide, or if you have any signs of ear infection or injury such as:

• 
  

  ear pain, itching, or other irritation;

  
  


• 
  

  drainage or discharge from the ear; or

  
  


• 
  

  bleeding from the ear.

  
  

FDA pregnancy category C. Before using this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Do not use this medication in a child younger than 12 years old without the advice of a doctor.

How should I use carbamide peroxide?

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

The usual dose of this medication for children is 1 to 5 drops per ear twice daily. The usual dose for adults is 5 to 10 drops per ear twice daily. Follow your doctor's instructions. Carbamide peroxide may be used for up to 4 days, unless your doctor has told you otherwise.

To use the ear drops, first remove the cap from the dropper bottle. Lie down or tilt your head with your ear facing upward. Pull back on your ear gently to open up the ear canal. Hold the dropper upside down over your ear canal and drop the correct number of ear drops into the ear.

You may hear a bubbling sound inside your ear after putting in the drops. This is caused by the foaming action of carbamide peroxide, which helps break up the wax inside your ear.

After using the ear drops, stay lying down or with your head tilted for at least 5 minutes. You may use a small piece of cotton ball to plug the ear and keep the medicine from draining out. Follow your doctor's instructions about the use of cotton.

Do not place the dropper tip into your ear, or allow the tip to touch any surface. It may become contaminated.

Wipe the tip of the medicine bottle with a clean tissue. Do not wash the dropper tip.

Carbamide peroxide may be packaged with a bulb syringe that is used to flush out your ear with water.

When filling the bulb syringe, use only warm water that is body temperature (no warmer than 98 degrees F). Do not use hot or cold water.

Hold your head sideways with your ear over a sink or bowl.

Gently pull your ear lobe back and downward to open up the ear canal. Place the tip of the bulb syringe at the opening of your ear canal. Do not insert the tip into your ear.

Squeeze the bulb syringe gently to release the water into your ear. Do not squirt the water with any force into your ear, or you could damage your ear drum.

Remove the syringe and allow the water to drain from your ear into the sink or bowl.

Do not use carbamide peroxide for longer than 4 days in a row. Call your doctor if your ear symptoms do not improve after treatment, or if they get worse.

Clean the bulb syringe by filling it with plain water and emptying it several times. Do not use soap or other cleaning chemicals. Allow the syringe to air dry.

Store the medication and the bulb syringe at room temperature away from moisture, heat, and direct light.

What happens if I miss a dose?

Since carbamide peroxide is used as needed, you may not be on a dosing schedule. If you are using the medication regularly, use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of carbamide peroxide is not likely to cause life-threatening symptoms.

What should I avoid while using carbamide peroxide?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using this medication.

Carbamide peroxide side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using carbamide peroxide and call your doctor at once if you have a serious side effect such as:

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  dizziness;

  
  


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  ear pain, itching, or other irritation;

  
  


• 
  

  discharge or bleeding from the ear; or

  
  


• 
  

  decreased hearing for a prolonged period of time.

  
  

Less serious side effects may include:

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  temporary decrease in hearing after using the ear drops;

  
  


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  mild feeling of fullness in the ear; or

  
  


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  mild itching inside the ear.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect carbamide peroxide?

It is not likely that other drugs you take orally or inject will have an effect on carbamide peroxided otic. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More Mollifene resources

• Mollifene Side Effects (in more detail)
• Mollifene Use in Pregnancy & Breastfeeding
• Mollifene Support Group
• 0 Reviews for Mollifene - Add your own review/rating

Compare Mollifene with other medications

• Ear Wax Impaction

Where can I get more information?

• Your pharmacist can provide more information about carbamide peroxide.

See also: Mollifene side effects (in more detail)