levobetaxolol Ophthalmic

lee-voe-be-TAX-oh-lol

Pharmacologic Class: Beta-Adrenergic Blocker, Cardioselective

Uses For levobetaxolol

Levobetaxolol is used alone or together with other medicines to treat increased pressure in the eye that is caused by open-angle glaucoma or a condition called ocular (eye) hypertension. levobetaxolol is a beta-blocker .

levobetaxolol was available only with your doctor's prescription .

Alcon Laboratories discontinued the distribution of levobetaxolol in 2006.

Before Using levobetaxolol

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For levobetaxolol, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to levobetaxolol or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatrics-specific problems that would limit the usefulness of levobetaxolol in children .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of levobetaxolol in the elderly .

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking levobetaxolol, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using levobetaxolol with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Albuterol


• Arformoterol


• Bambuterol


• Bitolterol


• Broxaterol


• Clenbuterol


• Colterol


• Dronedarone


• Fenoldopam


• Fenoterol


• Formoterol


• Hexoprenaline


• Indacaterol


• Isoetharine


• Levalbuterol


• Metaproterenol


• Pirbuterol


• Procaterol


• Reproterol


• Rimiterol


• Ritodrine


• Salmeterol


• Terbutaline


• Tretoquinol


• Tulobuterol

Using levobetaxolol with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aceclofenac


• Acemetacin


• Alclofenac


• Apazone


• Benoxaprofen


• Bromfenac


• Bufexamac


• Carprofen


• Clometacin


• Clonixin


• Dexketoprofen


• Diclofenac


• Diflunisal


• Dipyrone


• Droxicam


• Etodolac


• Etofenamate


• Felbinac


• Fenbufen


• Fenoprofen


• Fentiazac


• Floctafenine


• Flufenamic Acid


• Flurbiprofen


• Ibuprofen


• Indomethacin


• Indoprofen


• Isoxicam


• Ketoprofen


• Ketorolac


• Lornoxicam


• Meclofenamate


• Mefenamic Acid


• Meloxicam


• Nabumetone


• Naproxen


• Niflumic Acid


• Nimesulide


• Oxaprozin


• Oxyphenbutazone


• Phenylbutazone


• Pirazolac


• Piroxicam


• Pirprofen


• Propyphenazone


• Proquazone


• St John's Wort


• Sulindac


• Suprofen


• Tenidap


• Tenoxicam


• Tiaprofenic Acid


• Tolmetin


• Zomepirac

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of levobetaxolol. Make sure you tell your doctor if you have any other medical problems, especially:

• Bradycardia (slow heartbeat) or


• Heart block or


• Heart failure—Should not use in patients with these conditions .

• Diabetes or


• Hyperthyroidism (overactive thyroid) or


• Hypoglycemia (low blood sugar)—May cover up some of the signs and symptoms of these diseases, such as a fast heartbeat .

• Lung disease (e.g., asthma)—Use with caution. May cause difficulty with breathing in patients with this condition .

• Myasthenia gravis—May worsen symptoms of this condition, such as muscle weakness .

Proper Use of levobetaxolol

Shake the medicine well just before each use .

To use the eye drops (solution):

• First, wash your hands. Tilt the head back and, pressing your finger gently on the skin just beneath the lower eyelid, pull the lower eyelid away from the eye to make a space. Drop the medicine into this space. Let go of the eyelid and gently close the eyes. Do not blink. Keep the eyes closed and apply pressure to the inner corner of the eye with your finger for 1 or 2 minutes to allow the medicine to be absorbed by the eye.


• Immediately after using the medicine, wash your hands to remove any medicine that may be on them.


• To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed. Serious damage to the eye and possible loss of vision may result from using contaminated eye medicines .

If your doctor ordered two different eye medicines to be used together, wait several minutes before using the second medicine. This will help prevent the second medicine from “washing out” the first one .

You should not use levobetaxolol if you have contact lenses in your eyes. Remove your contact lenses before you use levobetaxolol, and wait 15 minutes before putting the lenses back in .

Dosing

The dose of levobetaxolol will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of levobetaxolol. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For ophthalmic solution dosage form (eye drops):
  
  • For glaucoma or ocular hypertension:
    
    • Adults and children—One drop in the affected eye(s) two times a day .
    
    
  
  

Missed Dose

If you miss a dose of levobetaxolol, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using levobetaxolol

It is very important that your doctor check your progress at regular visits to make sure levobetaxolol is working properly and to check for unwanted effects .

If itching, redness, swelling, or other signs of eye or eyelid irritation occur, stop using levobetaxolol and check with your doctor. These signs may mean that you are allergic to levobetaxolol .

Levobetaxolol may cause heart failure in some patients. Check with your doctor right away if you are having chest pain or discomfort; dilated neck veins; extreme fatigue; irregular breathing; an irregular heartbeat; shortness of breath; swelling of the face, fingers, feet, or lower legs; weight gain; or wheezing .

levobetaxolol may cause changes in your blood sugar levels. Also, levobetaxolol may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests .

Make sure any doctor or dentist who treats you knows that you are using levobetaxolol. You may need to stop using levobetaxolol several days before having surgery .

levobetaxolol Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Pain in the eye

Less common

• Blurred vision

Rare

• Ankle, knee, or great toe joint pain


• blindness


• bloody or cloudy urine


• body aches or pain


• breast swelling, redness, or tenderness


• change in vision


• chest pain or discomfort


• confusion


• congestion


• constipation


• continuing ringing or buzzing or other unexplained noise in ears


• cough producing mucus


• decreased vision


• depressed mood


• difficult or labored breathing


• difficult, burning, or painful urination


• difficulty in moving


• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly


• dry mouth


• dry skin and hair


• dryness or soreness of throat


• ear pain


• earache


• excessive muscle tone


• feeling cold


• fever or chills


• frequent urge to urinate


• hair loss


• headache


• hearing loss


• hoarseness or husky voice


• increased hunger


• increased thirst


• increased urination


• joint stiffness or swelling


• large amount of cholesterol in the blood


• large amount of fat in the blood


• lightheadedness, dizziness, or fainting


• looking through water


• loss of consciousness


• lower back or side pain


• muscle pain, cramps, and stiffness


• muscle tension or tightness


• nausea


• nervousness


• pain or redness in joints


• pain or tenderness around eyes and cheekbones


• pounding in the ears


• redness or swelling in the ear


• runny nose


• seeing floating spots before the eyes


• shortness of breath


• slow, fast, pounding, or irregular heartbeat or pulse


• sneezing


• stomachache


• stuffy nose


• sweating


• tender, swollen glands in neck


• tightness in chest


• trouble in swallowing


• troubled breathing


• unexplained weight loss


• unusual tiredness or weakness


• voice changes


• vomiting


• weight gain


• wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Dilated neck veins


• extreme fatigue


• irregular breathing


• swelling of face, fingers, feet, or lower legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

• Acid or sour stomach


• belching


• blistering, crusting, irritation, itching, or reddening of skin


• change in taste or bad, unusual, or unpleasant (after) taste


• cracked, dry, scaly skin


• fear, nervousness


• feeling of constant movement of self or surroundings


• heartburn


• indigestion


• sensation of spinning


• stomach discomfort, upset, or pain


• swelling

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: levobetaxolol Ophthalmic side effects (in more detail)

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More levobetaxolol Ophthalmic resources

• Levobetaxolol Ophthalmic Side Effects (in more detail)
• Levobetaxolol Ophthalmic Use in Pregnancy & Breastfeeding
• Levobetaxolol Ophthalmic Drug Interactions
• Levobetaxolol Ophthalmic Support Group
• 0 Reviews for Levobetaxolol Ophthalmic - Add your own review/rating

• levobetaxolol ophthalmic Concise Consumer Information (Cerner Multum)

Compare levobetaxolol Ophthalmic with other medications

• Glaucoma, Open Angle

Zyprexa Zydis

Generic Name: olanzapine (Oral route)

oh-LAN-za-peen

Oral route(Tablet;Tablet, Disintegrating)

Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death compared to placebo. Although the causes of death in clinical trials were varied, most of the deaths appeared to be either cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature. Observational studies suggest that antipsychotic drugs may increase mortality. It is unclear from these studies to what extent the mortality findings may be attributed to the antipsychotic drug as opposed to patient characteristics. Olanzapine is not approved for the treatment of patients with dementia-related psychosis .

Commonly used brand name(s)

In the U.S.

• Zyprexa


• Zyprexa Zydis

Available Dosage Forms:

• Tablet


• Tablet, Disintegrating

Therapeutic Class: Antipsychotic

Chemical Class: Thienobenzodiazepine

Uses For Zyprexa Zydis

Olanzapine is used to treat nervous, emotional, and mental conditions (e.g., schizophrenia). It may also be used alone or with other medicines (e.g., lithium or valproate) to treat bipolar disorder (manic-depressive illness) or mania that is part of bipolar disorder. This medicine should not be used to treat behavioral problems in older adult patients who have dementia or Alzheimer's disease.

This medicine is available only with your doctor's prescription.

Before Using Zyprexa Zydis

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of olanzapine in teenagers 13 to 17 years of age. However, safety and efficacy of olanzapine in children younger than 13 years of age have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of olanzapine in the elderly. However, elderly patients are more likely to have dementia or age-related liver, kidney, or heart problems, which may require caution or an adjustment in the dose for patients receiving olanzapine.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Levomethadyl


• Metoclopramide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Clomipramine


• Hydromorphone


• Lithium


• Milnacipran


• Mirtazapine


• Tetrabenazine


• Tramadol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Betel Nut


• Carbamazepine


• Ciprofloxacin


• Fluvoxamine


• Haloperidol


• Valproic Acid

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Blood vessel disease or circulation problems or


• Dehydration or


• Heart attack or stroke, history of or


• Heart disease or


• Heart failure or


• Heart rhythm problems or


• Hypotension (low blood pressure) or


• Hypovolemia (low blood volume)—May cause side effects to become worse.

• Breast cancer, prolactin-dependent or


• Glaucoma, narrow-angle or


• Hyperlipidemia (high cholesterol or fat in the blood) or


• Hyperprolactinemia (high prolactin in the blood) or


• Liver disease or


• Paralytic ileus (severe intestinal problem), history of or


• Prostatic hypertrophy (enlarged prostate) or


• Seizures, history of—Use with caution. This medicine may make these conditions worse.

• Diabetes or


• Hyperglycemia (high blood sugar)—This medicine may raise your blood sugar levels.

• Phenylketonuria (PKU, a genetic disease of metabolism)—The orally disintegrating tablet (Zyprexa® Zydis®) contains phenylalanine, which can make this condition worse.

Proper Use of olanzapine

This section provides information on the proper use of a number of products that contain olanzapine. It may not be specific to Zyprexa Zydis. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine should come with a medication guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the medication guide if you do not have one.

If you are using the orally disintegrating tablet (Zyprexa® Zydis®), make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil, then taking the tablet out. Do not push the tablet through the foil. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, swallow or take a sip of water.

You may take this medicine with or without food.

Tell your doctor if you smoke tobacco. You might need a different amount of this medicine if you smoke.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (orally disintegrating tablets, regular tablets):
  
  • For treatment of schizophrenia:
    
    • Adults—At first, 5 to 10 milligrams (mg) once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
    
    
    • Teenagers and children 13 to 17 years of age—At first, 2.5 or 5 milligrams (mg) once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
    
    
    • Children younger than 13 years of age—Use and dose must be determined by your doctor.
    
    
  
  
  • For treatment of bipolar disorder:
    
    • Adults—At first, 5 to 15 milligrams (mg) once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
    
    
    • Teenagers and children 13 to 17 years of age—At first, 2.5 or 5 milligrams (mg) once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
    
    
    • Children younger than 13 years of age—Use and dose must be determined by your doctor.
    
    
  
  
  • For treatment of mania with bipolar disorder:
    
    • Adults—At first, 10 to 15 milligrams (mg) once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
    
    
    • Teenagers and children 13 to 17 years of age—At first, 2.5 or 5 milligrams (mg) once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
    
    
    • Children younger than 13 years of age—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Zyprexa Zydis

It is very important that your doctor check your or your child's progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

For some patients, this medicine can increase thoughts of suicide. Tell your doctor right away if you or your child start to feel more depressed and have thoughts about hurting yourself. Report any unusual thoughts or behaviors that trouble you, especially if they are new or are getting worse quickly. Make sure the doctor knows if you or your child have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let the doctor know if you or anyone in your family has bipolar disorder (manic-depressive illness) or has tried to commit suicide.

This medicine may increase the amount of sugar in your blood. Check with your doctor right away if you have increased thirst or increased urination. If you or your child have diabetes, you may notice a change in the results of your urine or blood sugar tests. If you have any questions, check with your doctor.

This medicine may increase your cholesterol and fats in the blood. If this condition occurs, your doctor may give you or your child some medicines that can lower the amount of cholesterol and fats in the blood.

This medicine may increase your weight. Your doctor may need to check your or your child's weight on a regular basis while you are using this medicine.

Stop taking this medicine and check with your doctor right away if you or your child have any of the following symptoms while using this medicine: convulsions (seizures), difficulty with breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

This medicine may cause tardive dyskinesia (a movement disorder). Check with your doctor right away if you or your child have any of the following symptoms while taking this medicine: lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs.

Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.

This medicine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor immediately if you or your child think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.

Olanzapine may cause drowsiness, trouble with thinking, trouble with controlling body movements, or trouble with your vision. Make sure you know how you react to this medicine before you drive, use machines, or do other jobs that require you to be alert, well-coordinated, or able to think or see well.

This medicine may add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicines for allergies or colds; sedatives, tranquilizers, or sleeping medicines; prescription pain medicines or narcotics; medicines for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any CNS depressants while you are taking this medicine.

This medicine may make it more difficult for your body to cool down. It might reduce how much you sweat. Your body could get too hot if you do not sweat enough. If your body gets too hot, you might feel dizzy, weak, tired, or confused. You might vomit or have an upset stomach. Do not get too hot while you are exercising. Avoid places that are very hot. Call your doctor if you are too hot and can not cool down.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines) and herbal or vitamin supplements.

Zyprexa Zydis Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Bloating or swelling of the face, arms, hands, lower legs, or feet


• blurred vision


• change in vision


• change in walking and balance


• clumsiness or unsteadiness


• difficulty with speaking


• difficulty with swallowing


• drooling


• impaired vision


• inability to sit still


• loss of balance control


• mask-like face


• muscle trembling, jerking, or stiffness


• need to keep moving


• rapid weight gain


• restlessness


• shakiness in the legs, arms, hands, or feet


• shuffling walk


• slowed movements


• slurred speech


• stiffness of the arms and legs


• tic-like (jerky) movements of the head, face, mouth, and neck


• tingling of the hands or feet


• trembling or shaking of the fingers, hands, or feet


• twisting movements of the body


• uncontrolled movements, especially of the face, neck, and back


• unusual weight gain or loss

Less common

• Bladder pain


• bloody or cloudy urine


• bruising


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• chest pain


• difficult or labored breathing


• difficult, burning, or painful urination


• dizziness


• excessive muscle tone


• frequent urge to urinate


• headache


• inability to move the eyes


• increased blinking or spasms of the eyelid


• itching of the vagina or genital area


• lack of coordination


• large, flat, blue, or purplish patches in the skin


• loss of bladder control


• loss of memory


• lower back or side pain


• muscle tension or tightness


• nervousness


• pain during sexual intercourse


• pounding in the ears


• problems with memory


• rhythmic movement of the muscles


• shortness of breath


• slow, fast, pounding, or irregular heartbeat or pulse


• speaking is less clear than usual


• sticking out the tongue


• thick, white vaginal discharge with no odor or with a mild odor


• tightness in the chest


• trouble with breathing, speaking, or swallowing


• twitching


• uncontrolled twisting movements of the neck, trunk, arms, or legs


• unusual or incomplete body or facial movements


• weakness of the arms and legs


• wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Anxiety


• attacking, assaulting, or using force


• change in consciousness


• change in patterns and rhythms of speech


• confusion as to time, place, or person


• convulsions (seizures)


• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly


• drowsiness


• dry mouth


• fainting


• hallucinations


• heart stops beating


• high fever


• high or low blood pressure


• holding false beliefs that cannot be changed by fact


• increased sweating


• irregular, fast or slow, or shallow breathing


• irritability


• lightheadedness


• loss of consciousness


• mood or mental changes


• no breathing


• no pulse or blood pressure


• pale or blue lips, fingernails, or skin


• rapid breathing


• relaxed and calm


• severe muscle stiffness


• shaking or trembling


• sleepiness


• trouble with sleeping


• unconscious


• unusual excitement, nervousness, or restlessness


• unusual tiredness or weakness


• unusually pale skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Acid or sour stomach


• back pain


• belching


• change in personality


• difficulty having a bowel movement (stool)


• discouragement


• feeling sad or empty


• fever


• heartburn


• increased appetite


• increased cough


• indigestion


• lack of appetite


• lack or loss of strength


• loss of interest or pleasure


• runny nose


• sleeplessness


• sneezing


• stomach discomfort, upset, or pain


• stuffy nose


• thirst


• trouble with concentrating


• unable to sleep


• watering of the mouth


• weight gain

Less common

• Blemishes on the skin


• body aches or pain


• chills


• cold sweats


• congestion


• cough


• dry skin


• dryness or soreness of the throat


• false or unusual sense of well-being


• joint pain


• heavy menstrual bleeding (periods)


• hoarseness


• lack of feeling or emotion


• leg cramps


• pain in the arms or legs


• pimples


• sweating


• tender, swollen glands in the neck


• uncaring feelings


• voice change


• vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Zyprexa Zydis side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Zyprexa Zydis resources

• Zyprexa Zydis Side Effects (in more detail)
• Zyprexa Zydis Use in Pregnancy & Breastfeeding
• Drug Images
• Zyprexa Zydis Drug Interactions
• Zyprexa Zydis Support Group
• 12 Reviews for Zyprexa Zydis - Add your own review/rating

• Zyprexa Zydis Orally Disintegrating Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Olanzapine Monograph (AHFS DI)


• Olanzapine Professional Patient Advice (Wolters Kluwer)


• Olanzapine MedFacts Consumer Leaflet (Wolters Kluwer)


• Zyprexa MedFacts Consumer Leaflet (Wolters Kluwer)


• Zyprexa Consumer Overview


• Zyprexa Prescribing Information (FDA)


• Zyprexa Relprevv Prescribing Information (FDA)


• Zyprexa Relprevv MedFacts Consumer Leaflet (Wolters Kluwer)


• Zyprexa Relprevv Consumer Overview

Compare Zyprexa Zydis with other medications

• Anorexia
• Asperger Syndrome
• Bipolar Disorder
• Body Dysmorphic Disorder
• Borderline Personality Disorder
• Depression
• Insomnia
• Obsessive Compulsive Disorder
• Paranoid Disorder
• Schizoaffective Disorder
• Schizophrenia
• Tourette's Syndrome

Boots Hayfever Relief All Day 1mg / ml Syrup

1. Name Of The Medicinal Product

Boots Hayfever Relief All Day 1mg/ml Syrup (50ml, 60ml, 70ml or 100ml)

2. Qualitative And Quantitative Composition

Each ml of syrup contains 1mg loratadine.

The quantity of sucrose in the loratadine syrup composition is 600 mg/ml. The amount of sucrose per 5 ml (5 mg) dose is 3 grams.

For a full list of excipients, see section 6.1.

3. Pharmaceutical Form

Syrup

Clear, colourless to light yellow syrup.

4. Clinical Particulars

4.1 Therapeutic Indications

Boots Hayfever Relief All Day Syrup is indicated for the symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.

4.2 Posology And Method Of Administration

Adults and children over 12 years of age :

10mg once daily (10ml (10mg) of the syrup once daily).

The syrup may be taken without regard to mealtime.

Children 2 to 12 years of age are dosed by weight:

Body weight more than 30kg : 10mg once daily (10ml (10mg) of the syrup once daily).

Body weight 30kg or less : 5ml (5mg) of the syrup once daily.

Efficacy and safety of Boots Hayfever Relief All Day Syrup in children under 2 years of age has not been established.

Patients with severe liver impairment should be administered a lower initial dose because they may have reduced clearance of loratadine. An initial dose of 10mg every other day is recommended for adults and children weighing more than 30kg and for children weighing 30kg or less, 5ml (5mg) every other day is recommended.

No dosage adjustments are required in the elderly or in patients with renal insufficiency.

4.3 Contraindications

Boots Hayfever Relief All Day Syrup is contraindicated in patients who are hypersensitive to the active substance or to any of the excipients in these formulations.

4.4 Special Warnings And Precautions For Use

Boots Hayfever Relief All Day Syrup should be administered with caution in patients with severe liver impairment (see section 4.2).

This medicinal product contains sucrose; thus patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrose isomaltase insufficiency should not take this medicine.

The administration of Boots Hayfever Relief All Day Syrup should be discontinued at least 48 hours before skin tests since antihistamines may prevent or reduce otherwise positive reactions to dermal reactivity index.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

When administered concomitantly with alcohol, Boots Hayfever Relief All Day Syrup has no potentiating effects as measured by psychomotor performance studies.

Potential interaction may occur with all known inhibitors of CYP3A4 or CYP2D6 resulting in elevated levels of loratadine (see Section 5.2), which may cause an increase in adverse events.

4.6 Pregnancy And Lactation

Loratadine was not teratogenic in animal studies. The safe use of loratadine during pregnancy has not been established. The use of Boots Hayfever Relief All Day Syrup during pregnancy is therefore not recommended.

Loratadine is excreted in breast milk, therefore the use of loratadine is not recommended in breast-feeding women.

4.7 Effects On Ability To Drive And Use Machines

In clinical trials that assessed driving ability, no impairment occurred in patients receiving loratadine. However, patients should be informed that very rarely some people experience drowsiness, which may affect their ability to drive or use machines.

4.8 Undesirable Effects

In clinical trials in a paediatric population children aged 2 through 12 years, common adverse reactions reported in excess of placebo were headache (2.7%), nervousness (2.3%), and fatigue (1%).

In clinical trials involving adults and adolescents in a range of indications including AR and CIU, at the recommended dose of 10mg daily, adverse reactions with loratadine were reported in 2% of patients in excess of those treated with placebo. The most frequent adverse reactions reported in excess of placebo were somnolence (1.2%), headache (0.6%), increased appetite (0.5%) and insomnia (0.1%). Other adverse reactions reported very rarely during the post-marketing period are listed in the following table.

Immune System disorders	Anaphylaxis
Nervous system disorders	Dizziness
Cardiac disorders	Tachycardia, palpitation
Gastrointestinal disorders	Nausea, dry mouth, gastritis
Hepatobiliary disorders	Abnormal hepatic function
Skin and subcutaneous tissue disorders	Rash, alopecia
General disorders and administration site conditions	Fatigue

4.9 Overdose

Overdosage with loratadine increased the occurrence of anticholinergic symptoms. Somnolence, tachycardia and headache have been reported with overdoses.

In the event of overdose, general symptomatic and supportive measures are to be instituted and maintained for as long as necessary. Administration of activated charcoal as a slurry with water may be attempted. Gastric lavage may be considered. Loratadine is not removed by haemodialysis and it is not known if loratadine is removed by peritoneal dialysis. Medical monitoring of the patient is to be continued after emergency treatment.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Pharmacotherapeutic group : antihistamines – H₁ antagonist, ATC code : R06A X13.

Loratadine, the active ingredient in Boots Hayfever Relief All Day Syrup, is a tricyclic antihistamine with selective, peripheral H₁-receptor activity.

Loratadine has no clinically significant sedative or anticholinergic properties in the majority of the population and when used at the recommended dosage.

During long-term treatment there were no clinically significant changes in vital signs, laboratory test values, physical examinations or electrocardiograms.

Loratadine has no significant H₂-receptor activity. It does not inhibit norepinephrine uptake and has practically no influence on cardiovascular function or on intrinsic cardiac pacemaker activity.

5.2 Pharmacokinetic Properties

After oral administration, loratadine is rapidly and well absorbed and undergoes an extensive first pass metabolism, mainly by CYP3A4 and CYP2D6. The major metabolite-desloratadine (DL)- is pharmacologically active and responsible for a large part of the clinical effect. Loratadine and DL achieve maximum plasma concentrations (T_max) between 1-1.5 hours and 1.5-3.7 hours after administration, respectively.

Increase in plasma concentrations of loratadine has been reported after concomitant use with ketoconazole, erythromycin and cimetidine in controlled trials, but without clinically significant changes (including electrocardiographic).

Loratadine is highly bound (97% to 99%) and its active metabolite moderately bound (73% to 76%) to plasma proteins.

In healthy subjects, plasma distribution half-lives of loratadine and its active metabolite are approximately 1 and 2 hours, respectively. The mean elimination half-lives in healthy adult subjects were 8.4 hours (range = 3 to 20 hours) for loratadine and 28 hours (range = 8.8 to 92 hours) for the major active metabolite.

Approximately 40% of the dose is excreted in the urine and 42% in the faeces over a 10 day period and mainly in the form of conjugated metabolites. Approximately 27% of the dose is eliminated in the urine during the first 24 hours. Less than 1% of the active substance is excreted unchanged in active form, as loratadine or DL.

The bioavailability parameters of loratadine and of the active metabolite are dose proportional.

The pharmacokinetic profile of loratadine and its metabolites is comparable in healthy volunteers and in healthy geriatric volunteers.

Concomitant ingestion of food can delay slightly the absorption of loratadine but without influencing the clinical effect.

In patients with chronic renal impairment, both the AUC and peak plasma levels (C_max) increased for loratadine and its metabolite as compared to the AUCs and peak plasma levels (C_max) of patients with normal renal function. The mean elimination half-lives of loratadine and its metabolite were not significantly different from that observed in normal subjects. Haemodialysis does not have an effect on the pharmacokinetics of loratadine or its active metabolite in subjects with chronic renal impairment.

In patients with chronic alcoholic liver disease, the AUC and peak plasma levels (C_max) of loratadine were double while the pharmacokinetic profile of the active metabolite was not significantly changed from that in patients with normal liver function. The elimination half-lives for loratadine and its metabolite were 24 hours and 37 hours, respectively, and increased with increasing severity of liver disease.

Loratadine and its active metabolite are excreted in the breast milk of lactating women.

5.3 Preclinical Safety Data

Preclinical data reveal no special hazard based on conventional studies of safety, pharmacology, repeated dose toxicity, genotoxicity and carcinogenic potential.

In reproductive toxicity studies, no teratogenic effects were observed. However, prolonged parturition and reduced viability of offspring were observed in rats at plasma levels (AUC) 10 times higher than those achieved with clinical doses.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Propylene glycol (E1520);

Glycerin (E422);

Citric Acid Monohydrate;

Sodium Benzoate (E211);

Sucrose;

Artificial Peach Flavour;

Purified Water

6.2 Incompatibilities

None known

6.3 Shelf Life

24 months; after first opening, the syrup is stable for 1 month.

6.4 Special Precautions For Storage

This medicinal product does not require any special storage conditions.

Do not freeze.

Keep the bottle in the outer carton in order to protect from light.

6.5 Nature And Contents Of Container

Amber glass bottle of 60, 70, 100 or 120ml with a tamper-evident, child-proof, polypropylene cap. A 5ml plastic spoon is included.

Not all pack sizes may be marketed.

6.6 Special Precautions For Disposal And Other Handling

None.

7. Marketing Authorisation Holder

Merck Sharp & Dohme Limited

Hertford Road

Hoddesdon

Hertfordshire

EN11 9BU

UK

8. Marketing Authorisation Number(S)

PL 00025/0583

9. Date Of First Authorisation/Renewal Of The Authorisation

16^th March 1992/8^th November 2007

10. Date Of Revision Of The Text

11 January 2011

© Merck Sharp & Dohme Limited 2011. All rights reserved.

Boots Hayfever Relief All Day 1mg/ml Syrup/UK/02-11/01

ZoDerm Cream

Pronunciation: BEN-zoe-ill per-OX-ide/yoo-REE-ah
Generic Name: Benzoyl Peroxide/Urea
Brand Name: ZoDerm

ZoDerm Cream is used for:

Treating acne.

ZoDerm Cream is a keratolytic agent with antibacterial actions. The effectiveness of benzoyl peroxide appears to be due to its antibacterial, peeling (keratolytic), and drying actions.

Do NOT use ZoDerm Cream if:

• you are allergic to any ingredient in ZoDerm Cream

Contact your doctor or health care provider right away if any of these apply to you.

Before using ZoDerm Cream:

Some medical conditions may interact with ZoDerm Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with ZoDerm Cream. Because little, if any, of ZoDerm Cream is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if ZoDerm Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use ZoDerm Cream:

Use ZoDerm Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• To use the gel - Wash and completely dry the affected area. Gently rub the medicine in until it is evenly distributed.


• Wash your hands immediately after using ZoDerm Cream.


• Contact your doctor if the affected area becomes too dry or if excessive irritation develops. You may need to use less medicine or apply the medicine less often.


• Several weeks may pass before you see improvement in your acne. Continue to use ZoDerm Cream for the full time recommended by your doctor. If your acne does not improve or if it gets worse, check with your doctor.


• If you miss a dose of ZoDerm Cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use ZoDerm Cream.

Important safety information:

• Use on the skin only. Avoid getting ZoDerm Cream in your eyes, on the inside of your nose or mouth, on highly inflamed or damaged skin, or on your lips. If you get ZoDerm Cream in your eyes, immediately wash them out with cool tap water.


• Avoid applying ZoDerm Cream to raw or irritated skin, including sunburns, or to open wounds.


• Several weeks may pass before you see improvement in your acne. Continue to use ZoDerm Cream for the full time recommended by your doctor. If your acne does not improve or if it gets worse, check with your doctor.


• Talk with your doctor before you use any other medicines, special cleansers, aftershave, or cosmetics on your skin without checking with your doctor.


• ZoDerm Cream may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to ZoDerm Cream. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• ZoDerm Cream may cause bleaching. Avoid contact with hair, fabrics, or carpeting.


• ZoDerm Cream should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using ZoDerm Cream while you are pregnant. It is not known if ZoDerm Cream is found in breast milk. If you are or will be breast-feeding while you use ZoDerm Cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of ZoDerm Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dryness; feeling of warmth; irritation; itching; peeling; redness; stinging; swelling of the skin.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; dizziness; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); excessive burning, itching, redness, or tenderness of your skin; extreme dryness; swelling.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: ZoDerm side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include excessive scaling; flushing; redness; swelling.

Proper storage of ZoDerm Cream:

Store at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store in a tightly closed container, away from fire, flame, heat, and light. Do not store in the bathroom. Keep ZoDerm Cream out of the reach of children and away from pets.

General information:

• If you have any questions about ZoDerm Cream, please talk with your doctor, pharmacist, or other health care provider.


• ZoDerm Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about ZoDerm Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More ZoDerm resources

• ZoDerm Side Effects (in more detail)
• ZoDerm Use in Pregnancy & Breastfeeding
• ZoDerm Drug Interactions
• ZoDerm Support Group
• 0 Reviews for ZoDerm - Add your own review/rating

Compare ZoDerm with other medications

• Acne

Loxitane

Generic Name: loxapine (Oral route)

LOX-a-peen

Oral route(Capsule)

Elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death compared with placebo. Although the causes of death in clinical trials were varied, most of the deaths appeared to be either cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. It is unclear from these studies to what extent the mortality findings may be attributed to the antipsychotic drug as opposed to patient characteristics. Loxapine is not approved for the treatment of patients with dementia-related psychosis .

Commonly used brand name(s)

In the U.S.

• Loxitane

Available Dosage Forms:

• Tablet


• Capsule


• Solution

Therapeutic Class: Antipsychotic

Chemical Class: Dibenzoxazepine

Uses For Loxitane

Loxapine is used to treat a mental condition called schizophrenia.

This medicine is available only with your doctor's prescription.

Before Using Loxitane

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of loxapine in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of loxapine in geriatric patients. However, elderly patients (especially females) are more likely to have tardive dyskinesia (a movement disorder), which may require caution in patients receiving loxapine.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Metoclopramide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Hydromorphone


• Lithium


• Milnacipran


• Tramadol


• Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Betel Nut


• Carbamazepine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Brain tumor or


• Intestinal blockage—Loxapine may interfere with the diagnosis of these conditions.

• Breast cancer, prolactin-dependent or


• Difficult urination or


• Glaucoma or


• Heart or blood vessel disease or


• Neuroleptic malignant syndrome (NMS), history of or


• Seizures, history of or


• Urinary retention—Use with caution. May make these conditions worse.

• Coma or


• Depression, severe and caused by medicines—Should not be used in patients with these conditions.

Proper Use of Loxitane

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For schizophrenia:
  
  • For oral dosage form (capsules):
    
    • Adults—At first, 20 to 50 milligrams (mg) per day, divided and given in two to four doses per day. Your doctor may increase your dose if needed. However, the dose is usually not more than 250 mg per day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Loxitane

It is very important that your doctor check your progress at regular visits, especially during the first few months of treatment with this medicine. This will allow changes in your dose and to check for unwanted effects.

Do not stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping completely. This will allow your body time to adjust and to keep your condition from becoming worse.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever or allergies; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; medicine for seizures or barbiturates; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking this medicine.

This medicine may cause tardive dyskinesia (a movement disorder). Check with your doctor right away if you have any of the following symptoms while taking this medicine: lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs.

Stop taking this medicine and check with your doctor right away if you have any of the following symptoms while using this medicine: convulsions (seizures), difficulty with breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

This medicine may cause some people to become drowsy or less alert than they are normally, especially when the amount of medicine is increased. Even if you take this medicine at bedtime, you may feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert.

Although it is not a problem for most patients, dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. However, if the problem continues or gets worse, check with your doctor.

Loxapine may cause dry mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

Loxitane Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Difficulty with speaking or swallowing


• lip smacking or puckering


• loss of balance control


• mask-like face


• puffing of the cheeks


• rapid or fine, worm-like movements of the tongue


• restlessness or desire to keep moving


• shuffling walk


• slowed movements


• stiffness of the arms and legs


• trembling and shaking of the fingers and hands


• uncontrolled chewing movements


• uncontrolled movements of the arms or legs

Less common

• Constipation (severe)


• difficult urination


• inability to move the eyes


• muscle spasms, especially of the neck and back


• skin rash


• twisting movements of the body

Rare

• Convulsions (seizures)


• difficult or fast breathing


• fast heartbeat or irregular pulse


• fever (high)


• high or low blood pressure


• increased blinking or spasms of the eyelid


• increased sweating


• loss of bladder control


• muscle stiffness (severe)


• sore throat and fever


• uncontrolled twisting movements of neck, trunk, arms, or legs


• unusual bleeding or bruising


• unusual facial expressions or body positions


• unusual tiredness or weakness


• unusually pale skin


• yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Dizziness (severe)


• drowsiness (severe)


• muscle trembling, jerking, stiffness, or uncontrolled movements (severe)


• troubled breathing (severe)


• unusual tiredness or weakness (severe)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Blurred vision


• confusion


• dizziness, lightheadedness, or fainting


• drowsiness


• dryness of the mouth

Less common

• Constipation (mild)


• decreased sexual ability


• enlargement of breasts (males and females)


• headache


• increased sensitivity of the skin to sun


• missing menstrual periods


• nausea or vomiting


• trouble with sleeping


• unusual secretion of milk


• weight gain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Loxitane side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Loxitane resources

• Loxitane Side Effects (in more detail)
• Loxitane Use in Pregnancy & Breastfeeding
• Drug Images
• Loxitane Drug Interactions
• Loxitane Support Group
• 0 Reviews for Loxitane - Add your own review/rating

• Loxitane Prescribing Information (FDA)


• Loxitane MedFacts Consumer Leaflet (Wolters Kluwer)


• Loxitane Concise Consumer Information (Cerner Multum)


• Loxitane Monograph (AHFS DI)


• Loxapine Prescribing Information (FDA)


• Loxapine Professional Patient Advice (Wolters Kluwer)

Compare Loxitane with other medications

• Schizophrenia

Acnotex

Generic Name: sulfur topical (SULL fur)

Brand Names: Acnotex, Fostril, Liquimat Light, Liquimat Medium, Rezamid, Sulfo-Lo, Sulfoam, Sulforcin, Sulmasque, Sulpho-Lac, Sulpho-Lac Soap

What is Acnotex (sulfur topical)?

Topical sulfur causes drying and peeling of the skin. This allows excess oil and dirt to be easily washed away.

Sulfur topical is used to treat acne.

Sulfur topical may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Acnotex (sulfur topical)?

Do not use sulfur on sunburned, windburned, dry, chapped, or irritated skin or on open wounds.

Avoid abrasive, harsh, or drying soaps and cleansers while using sulfur topical.

Who should not use Acnotex (sulfur topical)?

Do not use sulfur topical on sunburned, windburned, dry, chapped, or irritated skin. It could make these conditions much worse. Also avoid using sulfur topical on wounds or on areas of eczema. Wait until these conditions have healed before using this medication.

Do not use sulfur topical during treatment with other topical acne products unless otherwise directed with your doctor. The combination could lead to severe skin irritation.

It is not known whether sulfur topical will harm an unborn baby. Do not use sulfur topical without first talking to your doctor if you are pregnant. It is also not known whether sulfur passes into breast milk. Do not use sulfur topical without first talking to your doctor if you are breast-feeding a baby.

How should I use Acnotex (sulfur topical)?

Use sulfur topical exactly as directed by your doctor, or follow the instructions that accompany the package. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after applying this medication.

Shake lotions well before using them. Clean and dry the area to which you will apply sulfur topical. Apply the medication to the affected area. When applying sulfur topical, avoid your eyes, the inside of your nose and mouth, your lips, and areas where the skin is broken to prevent excessive irritation. If you get medication in any of these areas, rinse it off with water.

Do not cover the affected area after applying sulfur topical, unless otherwise directed by your doctor. Doing so could cause too much medicine to be absorbed by your body and could be harmful.

Sulfur topical is usually applied one to three times daily.

It may take several weeks or more to see the effects of this drug. Do not stop using sulfur topical if you do not see results immediately.

Apply sulfur topical less often if you experience excessive burning, dryness, or irritation.

Store sulfur topical at room temperature away from moisture and heat.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and apply only your next regularly scheduled dose.

What happens if I overdose?

An overdose of sulfur topical is unlikely to occur. If you do suspect an overdose, or if sulfur topical has been ingested, call a poison control center or emergency room for advice.

What should I avoid while using Acnotex (sulfur topical)?

Do not use sulfur topical on sunburned, windburned, dry, chapped, or irritated skin or on open wounds.

Avoid using other topical products on the same area unless otherwise directed to do so by your doctor. They may interfere with the effects or absorption of sulfur topical.

Do not cover the area after applying sulfur topical, unless otherwise directed by your doctor. Doing so could cause too much medicine to be absorbed by your body and could be harmful.

Avoid using harsh, abrasive or irritating cleansers, perfumes or cosmetics on the area you are treating.

Acnotex (sulfur topical) side effects

Serious side effects are not likely to occur. Stop using sulfur topical and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).

You may experience some burning, stinging, tingling, itching, redness, dryness, peeling, or irritation while you are using sulfur topical. If these side effects are excessive, apply sulfur topical less often.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Acnotex (sulfur topical)?

Do not use other topical preparations unless directed to do so by your doctor. They may interfere with your treatment or increase irritation to your skin.

Avoid using harsh, abrasive or irritating cleansers, perfumes, or cosmetics on the area you are treating.

Drugs other than those listed here may also interact with sulfur topical. Talk to your doctor and pharmacist before taking any prescription or over the counter medicines.

More Acnotex resources

• Acnotex Side Effects (in more detail)
• Acnotex Use in Pregnancy & Breastfeeding
• Acnotex Drug Interactions
• Acnotex Support Group
• 1 Review for Acnotex - Add your own review/rating

• Sulfo-Lo Topical Advanced Consumer (Micromedex) - Includes Dosage Information

Compare Acnotex with other medications

• Acne

Where can I get more information?

• Your pharmacist has additional information about sulfur topical written for health professionals that you may read.

See also: Acnotex side effects (in more detail)

lincomycin

Generic Name: lincomycin (LIN koe mye sin)

Brand names: Bactramycin, Lincocin, Lincorex, L-Mycin

What is lincomycin?

Lincomycin is an antibiotic that fights serious infections caused by bacteria.

Lincomycin is used to treat severe bacterial infections in people who cannot receive penicillin antibiotics.

Lincomycin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about lincomycin?

Before receiving lincomycin, tell your doctor if you have asthma or allergies, a stomach or intestinal disorder such as colitis, liver or kidney disease, or epilepsy or other seizure disorder.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Serious side effects of lincomycin include fever, chills, body aches, flu symptoms, white patches or sores inside your mouth or on your lips, severe blistering or peeling skin rash, feeling like you might pass out, easy bruising or bleeding, unusual weakness, or urinating less than usual or not at all.

What should I discuss with my health care provider before receiving lincomycin?

You should not receive this medication if you are allergic to lincomycin or clindamycin (Cleocin).

Before receiving lincomycin, tell your doctor if you have:

• 
  

  asthma or allergies;

  
  


• 
  

  a stomach or intestinal disorder, such as colitis;

  
  


• liver or kidney disease; or


• 
  

  epilepsy or other seizure disorder.

  
  

If you have any of these conditions, you may not be able to receive lincomycin, or you may need a dose adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Lincomycin can pass into breast milk and may harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.

How is lincomycin given?

Lincomycin is given as an injection into a muscle, or through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection. You may be given instructions on how to inject your medicine at home. Do not use this medicine at home if you do not fully understand how to give the injection and properly dispose of needles and other items used in giving the medicine.

Lincomycin is usually given every 12 to 24 hours. Follow your doctor's instructions.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Lincomycin will not treat a viral infection such as the common cold or flu.

To be sure this medication is not causing harmful effects, your blood may need to be tested on a regular basis. Your kidney or liver function may also need to be tested.

If you store this medication at home, keep at room temperature away from moisture and heat.

What happens if I miss a dose?

Since lincomycin is usually given by a healthcare professional, it is not likely that you will miss a dose. If you are using lincomycin at home, call your doctor for instructions if you miss a dose.

What happens if I overdose?

Tell your caregivers right away if you think you have received too much of this medicine. Overdose symptoms may include chest pain, feeling light-headed, or fainting.

What should I avoid while receiving lincomycin?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Lincomycin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers right away if you have any of these serious side effects:

• 
  

  diarrhea that is watery or bloody;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  fever, chills, body aches, flu symptoms;

  
  


• 
  

  severe blistering, peeling, and red skin rash;

  
  


• 
  

  feeling like you might pass out;

  
  


• 
  

  easy bruising or bleeding, unusual weakness; or

  
  


• 
  

  white patches or sores inside your mouth or on your lips.

  
  

Less serious side effects include:

• 
  

  nausea, vomiting;

  
  


• 
  

  swollen or painful tongue;

  
  


• 
  

  vaginal itching or discharge;

  
  


• 
  

  mild itching or skin rash;

  
  


• 
  

  ringing in your ears; or

  
  


• 
  

  dizziness, spinning feeling.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Lincomycin Dosing Information

Usual Adult Dose for Bacterial Infection:

Intramuscular:
Serious infections: 600 mg IM every 24 hours
More severe infections: 600 mg IM every 12 hours, or more frequently

Intravenous:
Serious infections: 600 to 1000 mg IV every 8 to 12 hours
More severe infections: Dosage increases may be required
Life-threatening: Up to 8 g per day IV in divided doses
Dosage should be based upon the severity of the infection.

Usual Adult Dose for Bacterial Conjunctivitis:

75 mg subconjunctivally one time

Usual Pediatric Dose for Bacterial Infection:

2 months or older:
Intramuscular:
Serious infections: 10 mg/kg IM every 24 hours
More severe infections: 10 mg/kg IM every 12 hours, or more frequently

Intravenous: 10 to 20 mg/kg IV per day in 2 or 3 equally divided doses
Dosage should be based upon the severity of the infection.

What other drugs will affect lincomycin?

Before receiving lincomycin, tell your doctor if you are also using erythromycin (E-Mycin, E.E.S., Ery-Tab, Erythrocin, and others).

There may be other drugs that can interact with lincomycin. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More lincomycin resources

• Lincomycin Side Effects (in more detail)
• Lincomycin Dosage
• Lincomycin Use in Pregnancy & Breastfeeding
• Lincomycin Drug Interactions
• Lincomycin Support Group
• 0 Reviews for Lincomycin - Add your own review/rating

• lincomycin Oral, Injection Advanced Consumer (Micromedex) - Includes Dosage Information


• Lincomycin Professional Patient Advice (Wolters Kluwer)


• Lincomycin MedFacts Consumer Leaflet (Wolters Kluwer)


• Lincomycin Prescribing Information (FDA)


• Lincocin Monograph (AHFS DI)


• Lincocin Prescribing Information (FDA)

Compare lincomycin with other medications

• Bacterial Infection
• Conjunctivitis, Bacterial

Where can I get more information?

• Your doctor or pharmacist can provide more information about lincomycin.

See also: lincomycin side effects (in more detail)