Dihydroergotamine Spray

Pronunciation: dye-HYE-droe-er-GOT-a-meen
Generic Name: Dihydroergotamine
Brand Name: Migranal

A serious, life-threatening decrease in the amount of blood supply to the hands and feet (peripheral ischemia), and to the brain (cerebral ischemia) has been reported when Dihydroergotamine Spray was taken with certain other medicines. Do not take Dihydroergotamine Spray with macrolide antibiotics (eg, erythromycin, clarithromycin, troleandomycin), HIV protease inhibitors (eg, ritonavir, nelfinavir, indinavir), or azole antifungals (eg, ketoconazole, itraconazole, voriconazole).

Dihydroergotamine Spray is used for:

Treating acute migraine headache with or without aura (flashing lights, wavy lines, dark spots).

Dihydroergotamine Spray is an ergot derivative. It works by shrinking blood vessels in the brain, which helps to relieve migraine headaches.

Do NOT use Dihydroergotamine Spray if:

• you are pregnant, planning to become pregnant, or are breast-feeding


• you are allergic to any ingredient in Dihydroergotamine Spray or to other ergot derivatives (eg, ergotamine)


• you have a history of certain heart problems (eg, coronary artery disease or vasospasm, heart attack, angina)


• you have severe kidney or liver problems, uncontrolled high blood pressure, or certain types of migraine headaches (hemiplegic or basilar)


• you have blood vessel problems (eg, in the brain or heart, or throughout the body; peripheral blood vessel disease) or blood circulation problems


• you have recently had blood vessel surgery (including blood vessels in the heart)


• you have a serious infection of the blood


• you have used certain other migraine medicines, such as methysergide, a 5-HT₁ agonist (eg, sumatriptan), or other ergot derivatives (eg, ergotamine), within the last 24 hours


• you are taking delavirdine, efavirenz, an HIV protease inhibitor (eg, indinavir, nelfinavir, ritonavir), an imidazole antifungal (eg, itraconazole, ketoconazole, voriconazole), a ketolide antibiotic (eg, telithromycin), or a macrolide antibiotic (eg, clarithromycin, erythromycin, troleandomycin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Dihydroergotamine Spray:

Some medical conditions may interact with Dihydroergotamine Spray. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have risk factors for heart disease (eg, high blood pressure, high cholesterol, diabetes, smoking, are overweight, a family history of heart disease, a woman past menopause or if you have had your uterus removed [eg, hysterectomy], a man older than 40 years)


• if you have a history of the blood disease porphyria, heart problems, liver or kidney problems, chest pain, or shortness of breath


• if your migraine headache is different from previous migraines

Some MEDICINES MAY INTERACT with Dihydroergotamine Spray. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Clotrimazole, delavirdine, efavirenz, fluoxetine, fluvoxamine, HIV protease inhibitors (eg, indinavir, nelfinavir, ritonavir, saquinavir), imidazole antifungals (eg, fluconazole, itraconazole, ketoconazole, voriconazole), ketolide antibiotics (eg, telithromycin), macrolide antibiotics (eg, clarithromycin, erythromycin, troleandomycin), nefazodone, or zileuton because serious side effects may occur


• Beta blockers (eg, propranolol), delavirdine, efavirenz, 5-HT₁ agonists (eg, sumatriptan), methysergide, or other ergot derivatives (eg, ergotamine) because they may increase the risk of Dihydroergotamine Spray's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dihydroergotamine Spray may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Dihydroergotamine Spray:

An extra patient leaflet is available with Dihydroergotamine Spray. Talk to your pharmacist if you have questions about this information.

• Dihydroergotamine Spray comes with an additional patient leaflet. Read it carefully and reread it each time you get Dihydroergotamine Spray refilled.


• Check with your doctor before eating grapefruit or drinking grapefruit juice while taking Dihydroergotamine Spray.


• Dihydroergotamine Spray is for use in the nose only. It is not to be injected.


• Assemble the device according to the instructions provided with Dihydroergotamine Spray.


• Before you use Dihydroergotamine Spray, you will need to prime it. Remove the cap from the spray unit, hold the vial upright, and point the nasal sprayer away from your face. Pump the spray unit 4 times. Do not pump it more than 4 times.


• Spray 1 time into each nostril. Do NOT sniff or tilt your head back while spraying Dihydroergotamine Spray or immediately after.


• If more than 1 spray per nostril is to be used, wait 15 minutes between sprays. Do not exceed the recommended dose.


• After using Dihydroergotamine Spray, carefully throw away the nasal spray pump with the vial. Once a nasal spray vial has been opened, it must be thrown away after 8 hours.


• Do not assemble another vial of Dihydroergotamine Spray until you are ready to use it.


• If you miss a dose of Dihydroergotamine Spray and you still have a headache, follow your doctor's dosing instructions. Contact your doctor if you are unsure what to do if you miss a dose. Do not take Dihydroergotamine Spray more often than prescribed. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Dihydroergotamine Spray.

Important safety information:

• Dihydroergotamine Spray may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Dihydroergotamine Spray with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Tell your doctor or dentist that you take Dihydroergotamine Spray before you receive any medical or dental care, emergency care, or surgery.


• Do not use more than the recommended dose without checking with your doctor. Do not use Dihydroergotamine Spray daily on a regular basis.


• Dihydroergotamine Spray is not intended to prevent migraine headaches. Discuss any questions or concerns with your doctor.


• Use Dihydroergotamine Spray with caution in the ELDERLY; they may be more sensitive to its effects.


• Dihydroergotamine Spray should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Dihydroergotamine Spray has been shown to cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Dihydroergotamine Spray while you are pregnant. Dihydroergotamine Spray is found in breast milk. Do not breast-feed while taking Dihydroergotamine Spray

Possible side effects of Dihydroergotamine Spray:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in taste; dizziness; drowsiness; nasal discharge; nausea; nose or throat burning sensation, tingling, pain, soreness, or dryness; nosebleeds; runny or stuffy nose; sinus inflammation; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal skin sensations; fast, slow, or irregular heartbeat; itching; muscle pain, cramps, or weakness in the arms and legs; numbness, coldness, loss of color, bluish discoloration, or tingling in the fingers and toes; severe or persistent headache or dizziness; stomach pain, tenderness, or cramping; swelling; symptoms of heart attack (eg, chest, jaw, or left arm pain; fainting; numbness of an arm or leg; sudden, severe headache or vomiting; vision changes); symptoms of stroke (eg, confusion, one-sided weakness, slurred speech).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch .

See also: Dihydroergotamine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include coma; confusion; fainting; light-headedness; nausea; numbness, coldness, loss of color, bluish discoloration, tingling, or pain in the fingers or toes; seizures; severe dizziness or headache; slow or shallow breathing; stomach pain; vomiting.

Proper storage of Dihydroergotamine Spray:

Store Dihydroergotamine Spray below 77 degrees F (25 degrees C). Protect from heat, moisture, and light. Do not store in the bathroom. Do not refrigerate or freeze. Discard any remaining medicine 8 hours after the nasal spray vial has been prepared. Do not use after the expiration date. Keep Dihydroergotamine Spray out of the reach of children and away from pets.

General information:

• If you have any questions about Dihydroergotamine Spray, please talk with your doctor, pharmacist, or other health care provider.


• Dihydroergotamine Spray is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Dihydroergotamine Spray. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Dihydroergotamine resources

• Dihydroergotamine Side Effects (in more detail)
• Dihydroergotamine Use in Pregnancy & Breastfeeding
• Dihydroergotamine Drug Interactions
• Dihydroergotamine Support Group
• 12 Reviews for Dihydroergotamine - Add your own review/rating

Compare Dihydroergotamine with other medications

• Cluster Headaches
• Migraine

Bexxar 131 Iodine

Pronunciation: EYE-oh-dine/tos-IT-too-moe-mab
Generic Name: Iodine I 131/Tositumomab
Brand Name: Bexxar 131 Iodine

Bexxar 131 Iodine may cause serious allergic reactions, especially in patients who have received murine proteins previously. Seek immediate medical attention if you experience rash, itching, swelling, severe dizziness, or trouble breathing. Bexxar 131 Iodine may cause serious (possibly life-threatening) decreases in the number of white blood cells and platelets your body produces. This effect may last for a long period of time. Additional treatment may be needed to manage this effect. Serious infections or bleeding could occur as a result of low blood cell levels. Contact your doctor immediately if you experience fever, persistent sore throat, any other sign of infection, or unusual bruising or bleeding. Bexxar 131 Iodine must not be used during pregnancy because fetal harm can result. Contact your doctor immediately if you suspect that you could be pregnant.

Bexxar 131 Iodine is used for:

Treating certain forms of non-Hodgkin lymphoma in patients who have not responded to other therapy.

Bexxar 131 Iodine is a radioactive monoclonal antibody protein. It works by recognizing a protein receptor on cancer cells and then delivering radiation that increases the killing effect of the antibody.

Do NOT use Bexxar 131 Iodine if:

• you are allergic to any ingredient in Bexxar 131 Iodine or to mouse proteins


• you have bone marrow depression or a serious blood disorder such as low hemoglobin, white blood cells, or platelets


• you are pregnant


• you are unable to take a thyroid blocker (eg, methimazole)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Bexxar 131 Iodine:

Some medical conditions may interact with Bexxar 131 Iodine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have an infection, thyroid problems, or kidney problems


• if you are scheduled to receive a vaccine

Some MEDICINES MAY INTERACT with Bexxar 131 Iodine. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Medicines that decrease blood clotting (eg, aspirin, clopidogrel, ibuprofen, warfarin) and medicines that affect the immune system (eg, azathioprine, corticosteroids, cyclosporine) because serious side effects, such as risk of bleeding or infections, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Bexxar 131 Iodine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Bexxar 131 Iodine:

Use Bexxar 131 Iodine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Bexxar 131 Iodine is usually administered as an injection at your doctor's office, hospital, or clinic. Ask your doctor any question that you may have about Bexxar 131 Iodine.


• If you miss a dose of Bexxar 131 Iodine, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Bexxar 131 Iodine.

Important safety information:

• Bexxar 131 Iodine may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Bexxar 131 Iodine. Using Bexxar 131 Iodine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Bexxar 131 Iodine may reduce the number of certain blood cells, including red blood cells, white blood cells, and platelets. This may increase your risk of infection and bleeding. Prevent infection by avoiding contact with people with colds or other infections. Do not touch your eyes or the inside of your nose unless you have thoroughly washed your hands first. Notify your doctor of any signs of infection, including fever, sore throat, rashes, or chills. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding or bruising; blood in stools; or black, tarry stools to your doctor.


• Avoid vaccinations with live virus vaccines (eg, measles, mumps, oral polio) while you are taking Bexxar 131 Iodine.


• As with other cancer medicines, Bexxar 131 Iodine can cause a secondary cancer. Discuss the benefits and risks of using Bexxar 131 Iodine with your doctor.


• After receiving Bexxar 131 Iodine, the radioactive part of the dose will be in your body for several days. Follow all instructions you are given to minimize the exposure of others around you to this radioactivity.


• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Bexxar 131 Iodine.


• Bexxar 131 Iodine may reduce the levels of thyroid hormone your thyroid produces. Thyroid tests will be done before your doses and every year thereafter to monitor for any change in function of the thyroid gland.


• Some patients may develop an immune response called HAMA (human anti-murine antibody) after using Bexxar 131 Iodine. This antibody may interfere with certain lab test results. Be sure all of your doctors and laboratory personnel know that you are being treated, or have been treated, with Bexxar 131 Iodine.


• Both men and women capable of having children who receive Bexxar 131 Iodine should use reliable methods of birth control (eg, condoms) during and for at least 1 year after receiving Bexxar 131 Iodine.


• LAB TESTS, including complete blood cell counts, platelet counts, thyroid function tests, and kidney function tests, will be required to monitor your progress and check for side effects. Frequent monitoring will be done for up to 12 weeks after treatment. Be sure to keep all doctor and lab appointments.


• Caution is advised when using Bexxar 131 Iodine in the ELDERLY because they may be more sensitive to the effect Bexxar 131 Iodine has on blood cells.


• PREGNANCY and BREAST-FEEDING: Do not use Bexxar 131 Iodine if you are pregnant. If you think that you may be pregnant, contact your doctor immediately. Bexxar 131 Iodine is excreted in breast milk. Do not breast-feed while receiving Bexxar 131 Iodine.

Possible side effects of Bexxar 131 Iodine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; headache; muscle aches; nausea; pain, swelling, or redness at the injection site; stomach upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black stools; easy bruising or bleeding; fast heartbeat; flu-like symptoms such as chills, cough, or sweating; infection; itching; lightheadedness; loss of appetite; lung infection; new growths or lumps; pain, including chest, stomach, muscle, neck, back, or joint pain; pale skin; persistent sore throat or fever; shortness of breath; sudden weight loss; swelling of the hands or feet; unusual tiredness or weakness; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Bexxar31 Iodine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Bexxar 131 Iodine:

Bexxar 131 Iodine is radioactive and must be stored in the lead pot provided. It is usually handled and stored by a health care professional. Keep Bexxar 131 Iodine out of reach of children and away from pets.

General information:

• If you have any questions about Bexxar 131 Iodine, please talk with your doctor, pharmacist, or other health care provider.


• Bexxar 131 Iodine is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Bexxar 131 Iodine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Bexxar 131 Iodine resources

• Bexxar 131 Iodine Side Effects (in more detail)
• Bexxar 131 Iodine Use in Pregnancy & Breastfeeding
• Bexxar 131 Iodine Drug Interactions
• Bexxar 131 Iodine Support Group
• 0 Reviews for Bexxar31 Iodine - Add your own review/rating

Compare Bexxar 131 Iodine with other medications

• Non-Hodgkin's Lymphoma

Blistex Pro Relief

Generic Name: pramoxine topical (pra MOX een TOP i kal)

Brand Names: Anest Hemor, Blistex Pro Relief, Calaclear, Caladryl Clear, Callergy Clear, Curasore, Fleet Pain Relief Pad, Gold Bond Anti-Itch, Itch-X, PrameGel, Pramox, Prax, Proctofoam, Proctozone-P, Sarna Sensitive, Sarna Sensitive Eczema Itch Relief, Sarna Ultra, Soothe-It Plus Hemmorhoidal Pad, Summers Eve Anti-Itch, Tronolane

What is Blistex Pro Relief (pramoxine topical)?

Pramoxine is an anesthetic, or "numbing medicine." It works by interfering with pain signals sent from the nerves to the brain.

Pramoxine topical (for the skin) is used to treat pain or itching caused by insect bites, minor burns or scrapes, hemorrhoids, and minor skin rash, dryness, or itching. Pramoxine topical is also used to treat chapped lips, and pain or skin irritation caused by coming into contact with poison ivy, poison oak, or poison sumac.

Pramoxine topical may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Blistex Pro Relief (pramoxine topical)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects are more likely, and you may have none at all.

What should I discuss with my health care provider before using Blistex Pro Relief (pramoxine topical)?

You should not use this medication if you are allergic to pramoxine.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you are allergic to any drugs or any other numbing medicines.

FDA pregnancy category C. It is not known whether pramoxine topical will harm an unborn baby. Do not use this medication without medical advice if you are pregnant. It is not known whether pramoxine topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without medical advice if you are breast-feeding a baby.

How should I use Blistex Pro Relief (pramoxine topical)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Pramoxine is usually applied to the affected area 3 to 5 times daily, depending on which form of this medication you use. Follow the label directions or your doctor's instructions about how much medication to use and how often.

Pramoxine hemorrhoid cream, lotion, foam, or medicated wipe may be used on the rectum after each bowel movement to treat hemorrhoid pain and itching.

Wash your hands before and after applying pramoxine topical. Wash the affected skin area with warm water and a mild soap. Rinse and dry the area thoroughly.

To use pramoxine on the skin, (spray, lotion, gel, or stick), apply just enough of the medication to cover the area to be treated.

To use the pramoxine medicated wipe to treat the hemorrhoid area, apply the medication by patting the wipe onto the rectal area. Avoid harsh rubbing. You may fold the wipe and leave it in place for up to 15 minutes. Each pramoxine medicated wipe is for one use only. Throw the wipe away after using.

Shake the pramoxine rectal foam before each use. Squirt only a small amount of the medicine onto a clean tissue and apply it to your rectum. Do not insert this medication or the medicated wipe into your rectum. Use pramoxine topical only on the outside of the area.

Stop using pramoxine and call your doctor if your symptoms do not improve after 7 days of treatment, or if your condition clears up and then comes back.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since pramoxine topical is used on an as needed basis, you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Blistex Pro Relief (pramoxine topical)?

Avoid getting this medication in your eyes or nose. If this does happen, rinse with water. Do not use pramoxine topical on deep skin wounds, blistered skin, severe burns, or large skin areas. Seek medical attention for more severe skin irritation or injury.

Avoid using other medications on the areas you treat with pramoxine topical unless you doctor tells you to.

Blistex Pro Relief (pramoxine topical) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using pramoxine topical and call your doctor at once if you have a serious side effect such as:

• 
  

  any new redness or swelling where the medicine was applied; or

  
  


• 
  

  severe pain, burning, or stinging where the medicine is applied.

  
  

Less serious side effects are more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Blistex Pro Relief (pramoxine topical)?

It is not likely that other drugs you take orally or inject will have an effect on topically applied pramoxine. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More Blistex Pro Relief resources

• Blistex Pro Relief Side Effects (in more detail)
• Blistex Pro Relief Use in Pregnancy & Breastfeeding
• Blistex Pro Relief Support Group
• 0 Reviews · Be the first to review/rate this drug

• Caladryl Clear MedFacts Consumer Leaflet (Wolters Kluwer)


• Itch-X Foam MedFacts Consumer Leaflet (Wolters Kluwer)


• PrameGel Gel MedFacts Consumer Leaflet (Wolters Kluwer)


• Pramoxine Hydrochloride Monograph (AHFS DI)


• Prax Lotion MedFacts Consumer Leaflet (Wolters Kluwer)


• Proctofoam Foam MedFacts Consumer Leaflet (Wolters Kluwer)


• Sarna Sensitive Lotion MedFacts Consumer Leaflet (Wolters Kluwer)


• Tronolane Cream MedFacts Consumer Leaflet (Wolters Kluwer)

Where can I get more information?

• Your pharmacist can provide more information about pramoxine topical.

See also: Blistex Pro Relief side effects (in more detail)

brompheniramine, hydrocodone, and pseudoephedrine

Generic Name: brompheniramine, hydrocodone, and pseudoephedrine (brom fen EER a meen, hye droe KOE dohn, soo doe e FED rin)

Brand Names: Anaplex HD, Bromcomp HC, Bromph HD, Bromplex HD, BroveX HC, Drocon-CS, Endacof HC, J-Tan D HC, M-END, SymTan A, Visvex

What is brompheniramine, hydrocodone, and pseudoephedrine?

Brompheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Hydrocodone is in a group of drugs called narcotics and is similar to codeine. Hydrocodone is a cough suppressant that affects the signals in the brain that trigger cough reflex.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of brompheniramine, hydrocodone, and pseudoephedrine is used to treat cough, sneezing, itching, watery eyes, runny nose, stuffy nose, and sinus congestion caused by allergies, the common cold, or the flu.

Brompheniramine, hydrocodone, and pseudoephedrine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about brompheniramine, hydrocodone, and pseudoephedrine?

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not take this medication with alcohol, other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result. Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Hydrocodone should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Hydrocodone is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription. Do not use any other over-the-counter cough, cold, allergy, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant. This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

What should I discuss with my healthcare provider before taking brompheniramine, hydrocodone, and pseudoephedrine?

Do not use this medication if you are allergic to hydrocodone or other narcotic pain relievers such as fentanyl (Actiq, Duragesic), hydromorphone (Dilaudid, Palladone), methadone (Methadose, Dolophine), morphine (Kadian, MS Contin, Oramorph, and others), oxycodone (OxyContin), and oxymorphone (Opana). Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.

Before taking brompheniramine, hydrocodone, and pseudoephedrine, tell your doctor if you are allergic to any drugs, or if you have:

• 
  

  kidney or liver disease;

  
  


• 
  

  heart disease or high blood pressure;

  
  


• 
  

  enlarged prostate or urination problems;

  
  


• 
  

  diabetes;

  
  


• 
  

  glaucoma;

  
  


• 
  

  a thyroid disorder;

  
  


• 
  

  asthma, COPD, sleep apnea, or other breathing disorders;

  
  


• 
  

  a history of head injury or brain tumor;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  low blood pressure;

  
  


• 
  

  gallbladder disease;

  
  


• 
  

  Addison's disease or other adrenal gland disorders;

  
  


• 
  

  mental illness; or

  
  


• 
  

  a history of drug or alcohol addiction.

  
  

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category C. Hydrocodone may be harmful to an unborn baby, and could cause addiction or withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or plan to become pregnant during treatment. This medication may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Hydrocodone should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Hydrocodone is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

How should I take brompheniramine, hydrocodone, and pseudoephedrine?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Cough or cold medicine is usually taken for only a short time until your symptoms clear up.

Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.

This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

Store this medicine at room temperature, away from heat, light, and moisture.

See also: Brompheniramine, hydrocodone, and pseudoephedrine dosage (in more detail)

What happens if I miss a dose?

Since cough or cold medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of hydrocodone can be fatal. Overdose symptoms may include extreme dizziness or drowsiness, confusion, feeling restless or nervous, cold and clammy skin, warmth or tingly feeling, nausea, vomiting, slow or shallow breathing, slow heart rate, pinpoint pupils, fainting, seizure (convulsions), or coma.

What should I avoid while taking brompheniramine, hydrocodone, and pseudoephedrine?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid becoming overheated or dehydrated during exercise and in hot weather.

Do not drink alcohol while you are taking this medication. Alcohol can increase some of the side effects of brompheniramine, hydrocodone, and pseudoephedrine. Do not take this medication with other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Life-threatening side effects may result.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Do not use any other over-the-counter cough, cold, allergy, or sleep medication without first asking your doctor or pharmacist. Brompheniramine and pseudoephedrine are contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains brompheniramine or pseudoephedrine.

Brompheniramine, hydrocodone, and pseudoephedrine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

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  fast, pounding, or uneven heartbeats;

  
  


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  shallow breathing, slow heartbeat;

  
  


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  severe dizziness, fainting, anxiety, restless feeling, nervousness, or tremor;

  
  


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  confusion, hallucinations, unusual thoughts or behavior;

  
  


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  easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;

  
  


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  urinating less than usual or not at all; or

  
  


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  increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).

  
  

Less serious side effects may include:

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  blurred vision;

  
  


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  dry mouth;

  
  


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  nausea, vomiting, stomach pain, constipation, mild loss of appetite;

  
  


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  mild dizziness, drowsiness;

  
  


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  problems with memory or concentration;

  
  


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  ringing in your ears;

  
  


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  warmth, tingling, or redness under your skin;

  
  


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  restless or excitability (especially in children);

  
  


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  sleep problems (insomnia); or

  
  


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  skin rash or itching.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Brompheniramine, hydrocodone, and pseudoephedrine Dosing Information

Usual Adult Dose for Cough and Nasal Congestion:

Brompheniramine/hydrocodone/pseudoephedrine 2 mg-2.5 mg-15 mg/5 mL oral liquid:
10 mL orally every 4 to 6 hours.

Brompheniramine/hydrocodone/pseudoephedrine 3 mg-2.5 mg-15 mg/5 mL oral liquid:
5 to 10 mL orally every 4 to 6 hours not to exceed 40 mL daily.

Brompheniramine/hydrocodone/pseudoephedrine 6 mg-6 mg-45 mg/5 mL oral suspension, extended release:
5 mL orally every 12 hours not to exceed 10 mL daily.

Usual Pediatric Dose for Cough and Nasal Congestion:

Brompheniramine/hydrocodone/pseudoephedrine 2 mg-2.5 mg-15 mg/5 mL oral liquid:
6 to 11 years: 5 mL orally every 4 to 6 hours.
12 years or older: 10 mL orally every 4 to 6 hours.

Brompheniramine/hydrocodone/pseudoephedrine 3 mg-2.5 mg-15 mg/5 mL oral liquid:
2 to 5 years: 2.5 mL orally every 4 to 6 hours not to exceed 10 mL daily.
6 to 11 years: 5 mL orally every 4 to 6 hours not to exceed 20 mL daily.
12 years or older: 5 to 10 mL orally every 4 to 6 hours not to exceed 40 mL daily

Brompheniramine/hydrocodone/pseudoephedrine 6 mg-6 mg-45 mg/5 mL oral suspension, extended release:
6 to 11 years: 2.5 mL orally every 12 hours not to exceed 5 mL daily.
12 years or older: 5 mL orally every 12 hours not to exceed 10 mL daily.

What other drugs will affect brompheniramine, hydrocodone, and pseudoephedrine?

Before taking this medication, tell your doctor if you are using any of the following drugs:

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  cimetidine (Tagamet);

  
  


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  rifampin (Rifadin, Rifater, Rifamate, Rimactane);

  
  


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  zidovudine (Retrovir, AZT);

  
  


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  antidepressants such as amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others;

  
  


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  aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others);

  
  


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  a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others;

  
  


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  bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol);

  
  


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  a diuretic (water pill), or blood pressure medication;

  
  


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  medication to treat irritable bowel syndrome;

  
  


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  medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril); or

  
  


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  seizure medication such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton).

  
  

This list is not complete and there may be other drugs that can interact with brompheniramine, hydrocodone, and pseudoephedrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More brompheniramine, hydrocodone, and pseudoephedrine resources

• Brompheniramine, hydrocodone, and pseudoephedrine Side Effects (in more detail)
• Brompheniramine, hydrocodone, and pseudoephedrine Dosage
• Brompheniramine, hydrocodone, and pseudoephedrine Use in Pregnancy & Breastfeeding
• Brompheniramine, hydrocodone, and pseudoephedrine Drug Interactions
• Brompheniramine, hydrocodone, and pseudoephedrine Support Group
• 0 Reviews for Brompheniramine, hydrocodone, and pseudoephedrine - Add your own review/rating

Compare brompheniramine, hydrocodone, and pseudoephedrine with other medications

• Cough and Nasal Congestion

Where can I get more information?

• Your pharmacist can provide more information about brompheniramine, hydrocodone, and pseudoephedrine.

See also: brompheniramine, hydrocodone, and pseudoephedrine side effects (in more detail)

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